3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 36 Benzothiazol-6-yl- { (S)-3- [3- (4-fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}- methanone; A mixture of S-3- [3- (4-fluoro-phenyl)- [1, 2, 4] oxadiazol-5-yl]-piperidine hydrochloride (100 mg, 0.35 mmol, already prepared before in the Example 12), benzothiazole-6-carboxylic acid (70 mg, 0.38 mmol), HOAT (72 mg, 0. 52 mmol), PS- DCC (ex Argonaut Technologies, 0.59 g, 0.70 mmol, loading = 1. 2 mmol/g) and DIEA (90 mL, 0.52 mmol) in dry dichloromethane (6 mL) was kept overnight under orbital shaking (IKA Vibrax VXR). The resin was filtered off and washed repeatedly with dichloromethane; the filtrate was washed with HCl 1N (10 mL x 2 times) and with K2CO3 5% (aq. ) (10 mL x 2 times), then was dried over sodium sulphate and evaporated under reduced pressure. The crude was purified by flash chromatography (silica gel, eluent: DCM/MeOH 95/5) to give 50 mg ofbenzothiazol-6-yl- { (S)-3- [3- (4-fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-methanone. Yield: 35 % (white powder); mp=63-64C ; [a] D20 = +105 (c=1.0, CHCl3) ; LCMS (Tr): 5.39 min (Method A); MS (ES+) gave m/z : 409.1. ‘H-NMR (CDC13, 300 MHz), 8 (ppm): 9. 08 (s, 1H); 8.17 (d, 1H); 8. 07 (d, 1H); 8. 05 (m, 2H); 7.57 (dd, 1H); 7.16 (dd, 2H); 5.00-3. 71 (m br, 2H); 3.58 (m, 1H); 3.31 (m, 2H); 2.35 (m, 1H) ; 2.10-1. 87 (m, 2H); 1.72 (m, 1H)., 3622-35-3
As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.
Reference：
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica