With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59418-09-6,Methyl 4-thiazolecarboxylate,as a common compound, the synthetic route is as follows.
59418-09-6, A solution of 29 (0.014 mol) of methyl thiazole-4-carboxylate and 12 mL of 10% sodium hydroxide (0.03 mol) was added to a 100 mL three-necked flask and heated to reflux for 1 h.After cooling, a 20% HCl solution was added to the ice bath to neutralize pH = 3, and a solid was precipitated, suction filtered, and washed with a small amount of water.Drying gave the product thiazole-4-carboxylic acid 1.729 in a yield of 96.1%.
As the paragraph descriping shows that 59418-09-6 is playing an increasingly important role.
Reference：
Patent; Jiangsu Nuoen Crop Science Co., Ltd.; Meng Xianfeng; (9 pag.)CN109574953; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica