With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-00-1,2-Methyl-4,5-dihydrothiazole,as a common compound, the synthetic route is as follows.
EXAMPLE 7 2-Methyl-1,3-thiazoline (1.32 g) and pyridine (2.37 g) were dissolved in dichloromethane (50 ml) and cooled in an ice-bath. Chlorodifluoroacetic anhydride (6.3 g) was added to the above solution, dropwise, over 30 minutes. The mixture was then allowed to attain ambient temperature over 18 hours. The solvent was evaporated off under reduced pressure and the residue was suspended in water (50 ml) and treated with solid sodium bicarbonate until the solution became basic. The mixture was extracted with dichloromethane (3 x 75 ml), and the combined organic extract was dried over magnesium sulphate. The solvent was removed under reduced pressure and the residue recrystallized from ethanol to give a solid (2.4 g), 2-(chlorodifluoromethylcarbonylmethylene)-1,3-thiazolidine. mp 99°C. This intermediate compound (1.15 g) was dissolved in dimethyl formamide (15 ml, dried) and cooled in an ice-bath, with stirring and under a nitrogen gas atmosphere.
2346-00-1, 2346-00-1 2-Methyl-4,5-dihydrothiazole 16867, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; SHELL INTERNATIONALE RESEARCH, MAATSCHAPPIJ B.V.; EP652215; (1995); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica