90672-80-3,90672-80-3, 4-Bromo-2,5-dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
9-((l-(2,5-Dimethylthiazol-4-yl)-4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphi dihydro-8H-purin-8-one (1-514) (2052) (2053) [00536] Note: All reagents are solutions in THF unless specifically noted. Under an atmosphere of nitrogen, a mixture of 9-((4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphenyl)- 7,9-dihydro-8H-purin-8-one (11.08 mg, 30 muiotaetaomicron), sodium tert-butoxide (5.77 mg, 60.0 muiotaetaomicron), THF (250 mu , 4-bromo-2,5-dimethylthiazole (0.2M, 165 iL, 33.0 mumol), RuPhos precatalyst (0.02M, 75 uL, 1.500 mupiiotaomicron) and RuPhos (0.02M, 75 mu, 1.500 muiotaetaomicron) was heated to 100 C for 20 h. The reaction was concentrated, treated with saturated sodium bicarbonate (600 mu.) and extracted with EtOAc (2 x 600 mu.). The combined extracts were concentrated and purified by mass-directed preparative reverse phase HPLC to afford 1.0 mg (7% yield) of 9-((l-(2,5- dimethylthiazol-4-yl)-4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphenyl)-7,9-dihydro-8H- purin-8-one (1-514). LCMS Rt (min): 1.6817, m/z 481.44 [M+H]+.
As the paragraph descriping shows that 90672-80-3 is playing an increasingly important role.
Reference：
Patent; FORMA THERAPEUTICS, INC.; BUCKMELTER, Alexandre Joseph; IOANNIDIS, Stephanos; FOLLOWS, Bruce; GUSTAFSON, Gary; WANG, Minghua; CARAVELLA, Justin A.; WANG, Zhongguo; FRITZEN, Edward L.; LIN, Jian; (414 pag.)WO2017/87837; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica