With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19989-67-4,Benzo[d]thiazole-6-carbaldehyde,as a common compound, the synthetic route is as follows.
General procedure: rhodanine or hydantoine (1 eq), the corresponding aldehyde (1 eq) and sodium acetate (3eq) were dissolved in 5mL of acetic acid and the solution heated at 110C, if necessary under microwave conditions (130W for ?10min). After cooling, the precipitate was filtered off, washed to remove all the acetic acid and dried in vacuo. The reaction has been described in Mendgen etal. [39] to be stereospecific producing the Z-isomer as confirmed by the single peak in the HPLC. 4.1.2 Synthesis of (Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-thioxothiazolidin-4-one (16) Rhodanine (0.254 g, 1.84 mmol), 1,3-benzothiazole-6-carbaldehyde (0.300 g, 1.84 mmol) and sodium acetate (0.452 g, 5.51 mmol) were used following the general procedure A described above. Yield: 2%. Mp: > 300 C. 1H NMR (500 MHz, DMSO-d6) delta ppm 7.76 (d, J = 8.51 Hz, 1H) 7.78 (s, 1H) 8.21 (d, J = 8.51 Hz, 1H) 8.47 (s, 1H) 9.50-9.58 (m, 1H) 13.88 (br. s., 1H). 13C NMR (126 MHz, DMSO-d6) delta ppm 123.74 (s, 1C) 125.09 (s, 1C) 125.97 (s, 1C) 128.30 (s, 1C) 130.26 (s, 1C) 131.13 (s, 1C) 134.94 (s, 1C) 153.93 (s, 1C) 159.56 (s, 1C) 169.43 (s, 1C) 195.71 (s, 1C). LC-MS (ESI): m/z MH+ = 279.
19989-67-4, As the paragraph descriping shows that 19989-67-4 is playing an increasingly important role.
Reference：
Article; Mariano, Marica; Hartmann, Rolf W.; Engel, Matthias; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 209 – 216;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica