With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.943-03-3,6-Methoxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.
943-03-3, Pyridine hydrochloride (1.8 g, 15.57 mmol) was added to a 15 mL pressure tube and heated to 200 °C until completely dissolved.Then 2-cyano-6-methoxybenzothiazole (100 mg, 0.53 mmol) was added, followed by a reaction at 200 ° C for 2 h.The above reaction solution was adjusted to pH 7 with a 10percent NaHCO3 solution under ice bath. With EtOAc (15mL × 5) mixture was extracted, the organic layer was dried over anhydrous Na2SO4 and concentrated, the solvent was removed under reduced pressure.The crude product was purified by silica gel column chromatography (silica, hexane:EtOAc, 8:1 v/v).Obtained 50 mg of a white solid.The yield was 54.0percent.
943-03-3 6-Methoxybenzo[d]thiazole-2-carbonitrile 342109, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Xuzhou Medical University; Zhang Ling; Sheng Zhijia; Xue Yunsheng; Zheng Youguang; Zhang Yiran; Kai Xiaoning; (34 pag.)CN109293653; (2019); A;,
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