With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1011-40-1,2-Phenylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.
r°ip-theta-r°-phenyl-l^-thiazol-S-yDacrylic acid; To 2-phenyl-thiazole-5-carbaldehyde (888 mg, 4.69 mmol) is added malonic acid (684 mg, 6.57 mmol), pyridine (0.859 mL), and piperidine (0.046 mL). The resulting mixture is heated to reflux for six hours followed by cooling to rt. The reaction mixture is poured into water (20 mL) and after stirring for ten minutes, the resultant solid is filtered, rinsed with water, and dried under reduced pressure to afford the title compound (899 mg, 83% yield). 1H NMR delta 6.25 (d, 2H)5 7.53 (m, 3H)5 7.83 (d, IH), 7.95 (m, 2H)5 8.26 (s, IH)5 12.57 (br s, IH). LCMS (ES, M+H=232)., 1011-40-1
The synthetic route of 1011-40-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/106326; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica