288-47-1, Thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,288-47-1
The 5-amino-2-tolyl 2-thiazolylmethyl ether used as a starting material was obtained as follows: A solution of thiazole (5 g) in diethyl ether (50 ml) was added dropwise to n-butyl lithium (1.6M in hexane, 30 ml) which had been cooled to -70 C. and the mixture was stirred at -70 C. for 3 hours. Formaldehyde gas ?obtained by heating paraformaldehyde (5.05 g) to 140 C.! was led into the reaction mixture and the resultant mixture was allowed to warm to ambient temperature and was stirred for 16 hours. The mixture was partitioned between diethyl ether and 4M aqueous hydrochloric acid. The aqueous layer was basified by adding aqueous potassium hydroxide solution and extracted with a mixture of ethyl acetate (80 ml), chloroform (20 ml) and ethanol (20 ml). The extract was evaporated to give 2-thiazolylmethanol (.4.4 g), m.p. 46-47 C.;
The synthetic route of 288-47-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zeneca Limited; US5821246; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica