With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,96929-05-4
a. Tert-butyl N-[[4-(hydroxymethyl)thiazol-2-yl]methyl]carbamate To a stirred solution of ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate (1 g, 3.49 mmol) in THF (20 mL) was added LiAlH4 (7.0 mL, 6.98 mmol, 1M in THF) drop wise under nitrogen at 0 C and the reaction mixture was allowed stir at room temperature for 4 h. The reaction mixture was cooled to 0 C and quenched with EtOAc (30 mL) followed by saturated aqueous sodium sulphate solution. Then stirred at same temperature for 30 min., filtered and filtrate was evaporated. The crude was chromatographed on silica eluting with 40% EtOAc in petroleum ether affording a yellow solid (510 mg, 59%). M/z 245.1 (M+H)+.
The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Antabio SAS; The designation of the inventor has not yet been filed; (149 pag.)EP3628672; (2020); A1;,
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