Day: March 18, 2022

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 25 mL of a 10 M potassium hydroxide solution, 5 g of 2-amino-6-bromo-benzothiazole was added, and then a mixed solution of 5 mL of ethylene glycol was added thereto, and the mixture was stirred at 125 C for 2 hours.Obtaining 2-amino-5-bromobenzenethiol;

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Nanjing Zhongpengliankang Medical Treatment Technology Co., Ltd.; Liu Yuanhao; (20 pag.)CN108239100; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

824403-26-1, Intermediate 1: Step b3-((5-Bromobenzo [d] thiazol-2-yl)amino)-4-methoxybenzonitrileCommercially available 5-bromo-2-chlorobenzo[d]thiazole (2.0 g, 8.05 mmol) in phenol (4 g) was treated with 3-amino-4-methoxybenzonitrile (1.31 g, 8.85 mmol, intermediate 1, step a). The mixture was heated to 100 C overnight. The resulting red-brown solution was cooled to room temperature. To the solid formed upon cooling was added EtOAc and saturated aqueous NaHCC solution. The mixture was stirred for 1 h to dissolve the solid. The aqueous layer was separated out. The organic layer was washed with IN NaOH solution for 5 times to get rid of phenol. The organic layer was dried (MgS04) and concentrated in vacuo to obtain the title compound as a solid.

The synthetic route of 824403-26-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; JACKSON, Paul, Francis; MAHAROOF, Umar, S.M.; LEONARD, Kristi, Anne; BAXTER, Ellen; TOUNGE, Brett, Andrew; HAWKINS, Michael; WO2012/162463; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

64987-16-2, A solution of methyl 2-(2-aminothiazol-4-yl)acetate (3.56 g, 20.7 mmol) and DMAP (0.25 g, 2.07 mmol) in pyridine (16.74 ml_, 207 mmol) was cooled to 0 C whereupon methanesulfonyl chloride (1.61 ml_, 20.70 mmol) was added dropwise. The yellow solution was allowed to warm to RT and stirred for 1 hr then added to 1 M HCI (aq, 228 ml.) and stirred for 30 min. The resulting precipitate was then filtered and washed with Et20 (10 ml.) to afford a yellow solid. This was slurried in Et20 (20 ml.) and filtered to afford methyl 2-(2-(methylsulfonamido)thiazol-4-yl)acetate (3.56 g, 13.94 mmol, 67 % yield) as a colourless solid; Rt 0.83 min (HPLC acidic); m/z 251 (M+H)+ (ES+); 249 (M-H)- (ES-); 1H NMR (400 MHz, DMSO-d6) d 12.47 (s, 1 H), 6.60 (s, 1 H), 3.67 (d, J = 0.9 Hz, 2H), 3.66 (s, 3H), 2.90 (s, 3H).

The synthetic route of 64987-16-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; STEP PHARMA S.A.S.; QUDDUS, Abdul; NOVAK, Andrew; COUSIN, David; CHATZOPOULOU, Elli; BLACKHAM, Emma; JONES, Geraint; THOMAS, Jennifer; WRIGGLESWORTH, Joseph; DUFFY, Lorna; BIRCH, Louise; GEORGE, Pascal; AHMED, Saleh; (277 pag.)WO2019/106156; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64987-16-2,Methyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,64987-16-2

Step B: methyl 2-(2-(tert-butoxycarbonylamino)thiazol-4-yl)acetate A solution of di-tert-butyl dicarbonate (279 mg, 1.28 mmol) in toluene (3 ml) was added a vessel containing methyl 2-(2-aminothiazol-4-yl)acetate (200 mg, 1.16mmol), the reaction mixture was heated at 85 C for 24h. LCMS showed that the desired product was detected, the mixture was concentrated to give the residue, the residue was purified by a standard method to give the desired product. LC-MS : m/z (M+H)= 273.3

The synthetic route of 64987-16-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey O.; TRAVINS, Jeremey; CHEN, Yongsheng; WO2014/79150; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.494769-34-5,N-Boc-2-Amino-4-formylthiazole,as a common compound, the synthetic route is as follows.

TFA (2.0 mL) was added to a 0 C. solution of Part A compound (0.64 g; 2.80 mmol) in DCM (4.0 mL). After 20 h at RT the reaction mixture was concentrated in vacuo. The residue was partitioned between EtOAc (10 mL) and sat. aqueous NaHCO3 (8 mL). The aqueous phase was isolated and extracted with EtOAc (5×8 mL). The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give Part B compound (0.30 g; 83%) as a yellow solid., 494769-34-5

As the paragraph descriping shows that 494769-34-5 is playing an increasingly important role.

Reference：
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-72-8,4175-72-8, 4-Chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of 4-methoxythiazole (9): A mixture of sodium methoxide, prepared by treating 450 mL of methanol with 21 g (913 mmol) of sodium metal, and 29.3 g (245 mmol) of 4-chlorothiazole (8) was refluxed for 24 hours. The mixture was cooled to room temperature and was reduced in volume by about half by concentrating on a rotovap. The mixture was dissolved in 500 mL of water and extracted with diethyl ether (500 mL, then 3*200 mL). The combined ethereal extracts were washed with 500 mL of brine, dried over MgSO4, filtered, and concentrated in vacuo. The resulting red oil was purified by flash chromatography (silica gel, 5.5*30 cm, chloroform) and then by vacuum distillation to give 17.5 g (62% yield) of 4-methoxythiazole (9) as a colorless liquid. 1H NMR (500 MHz) delta 8.58 (d, 1H, J=2.2 Hz), 6.16 (d, 1H, J=2.3 Hz), 3.96 (s, 3H).

As the paragraph descriping shows that 4175-72-8 is playing an increasingly important role.

Reference：
Patent; Watson, Mark D.; US2010/252112; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15448-99-4,2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide,as a common compound, the synthetic route is as follows.

EXAMPLE 6 Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (I; Y=OCH3) To a solution of 2.9 g. (0.015 mole) of N-methylsaccharin and 2.63 g. (0.03 mole) of methylchloroacetate in 10 ml. of dimethylformamide at 40 C. was added over a period of two hours 864 mg. (0.036 mole) of 99% sodium hydride. Stirring was continued for two hours, maintaining a reaction temperature of 40-50 C. The reaction mixture was quenched in 150 ml. of 5% hydrochloric acid, and the precipitated product filtered and dried, 3.41 g. (84%)., 15448-99-4

15448-99-4 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide 27290, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Pfizer Inc.; US4376204; (1983); A;; ; Patent; Pfizer Inc.; US4483982; (1984); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

15864-32-1, Step 6; To a solution of 2-amino-6-bromobenzothiazole (10 g, 0.044 mol) in dichloromethane (150 mL), DMAP (7 g) and acetic anhydride (18 g) were added. The solution was then refluxed overnight. The reaction mixture was concentrated, and then water was added thereto. The precipitate was collected by filtration, then washed with water and dried to yield target compound 50 (10.2 g, y. 85%).

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Shionogi & Co., Ltd.; EP2426135; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1011-40-1,2-Phenylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

r°ip-theta-r°-phenyl-l^-thiazol-S-yDacrylic acid; To 2-phenyl-thiazole-5-carbaldehyde (888 mg, 4.69 mmol) is added malonic acid (684 mg, 6.57 mmol), pyridine (0.859 mL), and piperidine (0.046 mL). The resulting mixture is heated to reflux for six hours followed by cooling to rt. The reaction mixture is poured into water (20 mL) and after stirring for ten minutes, the resultant solid is filtered, rinsed with water, and dried under reduced pressure to afford the title compound (899 mg, 83% yield). 1H NMR delta 6.25 (d, 2H)5 7.53 (m, 3H)5 7.83 (d, IH), 7.95 (m, 2H)5 8.26 (s, IH)5 12.57 (br s, IH). LCMS (ES, M+H=232)., 1011-40-1

The synthetic route of 1011-40-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/106326; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-00-1,2-Methyl-4,5-dihydrothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 7 2-Methyl-1,3-thiazoline (1.32 g) and pyridine (2.37 g) were dissolved in dichloromethane (50 ml) and cooled in an ice-bath. Chlorodifluoroacetic anhydride (6.3 g) was added to the above solution, dropwise, over 30 minutes. The mixture was then allowed to attain ambient temperature over 18 hours. The solvent was evaporated off under reduced pressure and the residue was suspended in water (50 ml) and treated with solid sodium bicarbonate until the solution became basic. The mixture was extracted with dichloromethane (3 x 75 ml), and the combined organic extract was dried over magnesium sulphate. The solvent was removed under reduced pressure and the residue recrystallized from ethanol to give a solid (2.4 g), 2-(chlorodifluoromethylcarbonylmethylene)-1,3-thiazolidine. mp 99°C. This intermediate compound (1.15 g) was dissolved in dimethyl formamide (15 ml, dried) and cooled in an ice-bath, with stirring and under a nitrogen gas atmosphere.

2346-00-1, 2346-00-1 2-Methyl-4,5-dihydrothiazole 16867, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SHELL INTERNATIONALE RESEARCH, MAATSCHAPPIJ B.V.; EP652215; (1995); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica