With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
824403-26-1, Intermediate 1: Step b3-((5-Bromobenzo [d] thiazol-2-yl)amino)-4-methoxybenzonitrileCommercially available 5-bromo-2-chlorobenzo[d]thiazole (2.0 g, 8.05 mmol) in phenol (4 g) was treated with 3-amino-4-methoxybenzonitrile (1.31 g, 8.85 mmol, intermediate 1, step a). The mixture was heated to 100 C overnight. The resulting red-brown solution was cooled to room temperature. To the solid formed upon cooling was added EtOAc and saturated aqueous NaHCC solution. The mixture was stirred for 1 h to dissolve the solid. The aqueous layer was separated out. The organic layer was washed with IN NaOH solution for 5 times to get rid of phenol. The organic layer was dried (MgS04) and concentrated in vacuo to obtain the title compound as a solid.
The synthetic route of 824403-26-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICA NV; JACKSON, Paul, Francis; MAHAROOF, Umar, S.M.; LEONARD, Kristi, Anne; BAXTER, Ellen; TOUNGE, Brett, Andrew; HAWKINS, Michael; WO2012/162463; (2012); A1;,
Thiazole | C3H3NS – PubChem
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