With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: Route 1: To a suspension of N-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) (100 mg, 0.520 mmol) inTHF (5 mL) under Ar atmosphere were added 1-hydroxybenzotriazole(HOBt) (60 mg, 0.440 mmol) and the corresponding carboxylicacid (b-f) (0.400 mmol). After 30 min, 4-(benzo[e][1,2]azaborinin-2(1H)-ylmethoxy)-N-methylaniline (6) (106 mg, 0.400 mmol) followed by Et3N (121 mg, 167 lL, 1.20 mmol) were added at 0 Cand the mixture was allowed to warm to RT overnight (16 h). Thecrude mixture was then diluted with EtOAc (25 mL) and washedwith satd aq NH4Cl (3 25 mL) then brine (25 mL). The organicphase was isolated and dried over Na2SO4, filtered, and the solventwas removed in vacuo. The crude residue was further purified bygradient column chromatography (SiO2, flash, 0-100%EtOAc/heptane) to isolate the title compounds (2b-f) after solventremoval., 3622-35-3
3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.
Reference：
Article; Vlasceanu, Alexandru; Jessing, Mikkel; Kilburn, John Paul; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4453 – 4461;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica