Analyzing the synthesis route of 425392-45-6

The synthetic route of 425392-45-6 has been constantly updated, and we look forward to future research findings.

425392-45-6, Ethyl 5-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,425392-45-6

20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216 C.; 1H NMR (DMSO-d6) 7.69 (1H, s); 7.83 (1H, s); 9.05 (1H, s).

The synthetic route of 425392-45-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao; US2010/87448; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica