Day: March 22, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

B) A microwave vial was charged with 5-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.300 g, 1.61 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) (0.28 g, 0.48 mmol) and palladium dibenzylideneacetone (Pd2dba3)-chloroform complex (0.17 g, 0.16 mmol). Degassed dioxane (15.00 ml) was added, followed by 3-bromobenzenesulfonamide (0.38 g, 1.61 mmol) and cesium carbonate (0.93 g, 2.87 mmol) The vial was then irradiated in a microwave oven at 150 C. for 15 min. The mixture was diluted with THF and the solids filtered, washing with THF. The filtrate was evaporated and the residue purified by flash chromatography (heptane ethyl acetate) to yield 2-methyl-5-(3-sulfamoyl-phenylamino)-thiazole-4-carboxylic acid ethyl ester (0.13 g, 24%) as an off-white solid

31785-05-4, As the paragraph descriping shows that 31785-05-4 is playing an increasingly important role.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-30-8,2,4-Dichlorobenzothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 164 (+)-(4aR)-(10bR)-4-methyl-8-(4-chloro-2-benzothiazolylthio)-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one STR181 A 15 mL round bottom flask was charged with (+)-(4aR)-(10bR)-4-methyl-8-mercapto-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one (100 mg, 0.38 mmol), potassium carbonate (158 mg, 1.14 mmol), 2,4-dichlorobenzothiazole (94 mg, 0.46 mmol) and 1 mL of anhydrous dimethyl formamide, fitted with a reflux condenser, and the stirred mixture was heated at 60°, under nitrogen, for 48 h. The mixture was cooled, diluted with ethyl acetate (75 mL) and washed with brine (2*25 mL). The combined organic extracts were dried over sodium sulfate, concentrated, and purified by silica gel chromatography (80percent ethyl acetate/hexanes eluent) to give 80 mg (49percent) of the title compound as an amorphous solid. mp 207°-209°. FDMS: m/e=429 alpha[D]589 =+63.86 (c=0.57, chloroform).

3622-30-8, As the paragraph descriping shows that 3622-30-8 is playing an increasingly important role.

Reference：
Patent; Eli Lilly and Company; US5578724; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14779-17-0, 2-Amino-5-methylbenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14 parts of 2-amino-5-methyl-benzothiazole and 11 parts of 1-amino-anthraquinone-2-aldehyde are suspended in 100 parts of N,N-dimethylformamide. 0.2 part of acetic acid is added and the red solution is heated to 140C for 8 hours under nitrogen atmosphere. After cooling to 25C, the suspension is filtered and the cake is washed successively with N,N-dimethylformamide and methanol and then dried. This gives 15 parts of a violet-colored powder., 14779-17-0

As the paragraph descriping shows that 14779-17-0 is playing an increasingly important role.

Reference：
Patent; CLARIANT INTERNATIONAL LTD.; EP1447430; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

943-03-3,943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridine hydrochloride (1.0 g, 8.65 mmol) and 2-cyano-6-methoxybenzothiazole, 2, (0.5 g, 2.63 mmol) were added to a 5 mL microwave flask with a stirbar. Nitrogen gas was added to the reaction vessel immediately before it was shut. The flask was heated to 200° C. using a power level of 150 W for 40 minutes in a Biotage microwave synthesizer. The reaction was stirred at 600 rpm. The reaction was cooled and neutralized with sodium bicarbonate. During neutralization, the crude product precipitated from the solution as a yellow solid. The precipitate was filtered, and the filtrate was washed three times with ethyl acetate. Combination of the crude product from the ethyl acetate washes and the yellow precipitate and purification on a silica column (70:30 hexanes:ethyl acetate, dry loaded) yielded 408.7 mg (88percent) of the pure product. 1H NMR (300 MHz, CD3OD): delta 7.13 (1H, dd, J=9 Hz), 7.36 (1H, d, J=2.1 Hz), 7.95 (1H, d, J=9 Hz). LRESI-MS: calculated for [C8H4N2OS] 176.0. found 176.1.

943-03-3 6-Methoxybenzo[d]thiazole-2-carbonitrile 342109, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; The Regents of the University of California; Chang, Christopher J.; van de Bittner, Genevieve C.; Dubikovskaya, Elena A.; Bertozzi, Carolyn R.; US2013/315829; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-51-9, Benzo[d]thiazol-4-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of BSCA (0.5 g, 2mmol) and thionyl chloride(20mL) was stirred at reflux for 2 h. The reaction was monitoredby IR spectroscopy. Formation of the acyl chloride was confirmedfollowing the wavenumber position in infrared spectroscopypeaks: carbonyl group showed up around: 1682 cm-1 and thesimple bond of OH group was detected around 3448 cm-1 in thestarting acid whereas the carbonyl in the acyl chloride arosearound 1750 cm-1. The resulting acyl chloride was isolated byrotatory evaporation of the thionyl chloride under vacuum andthe excess of thionyl chloride was removed with 3 fractions oftoluene (40mL). The resulting acyl chloride was used withoutfurther purification. A solution of the corresponding amine(2mmol) in dry chloroform (15mL) was added to a mixture ofacyl chloride (0.5 g, 2mmol) and triethylamine (0.28mL, 2mmol)in dry chloroform (40mL). The mixture was stirred at roomtemperature for 12-48 h. The product was isolated by filtrationor by rotatory evaporation of the solvent under vacuum andwashed with water (3 50 mL). Final product was purified bywashing, recrystallization, or column chromatography., 1123-51-9

The synthetic route of 1123-51-9 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Ruberte, Ana Carolina; Plano, Daniel; Encio, Ignacio; Aydillo, Carlos; Sharma, Arun K.; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 14 – 27;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14769-73-4, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml four-mouth bottle into L-tetramisole 50g, inputs isopropanol 500g, heating is dissolved, add activated carbon 0.5g, sodium metabisulfite 0.75g stirring decolourizations 30 minutes, filtration, filtrate hydrogen chloride gas under stirring 9g, to pH4-5, filtering, levamisole hydrochloride dried to get 54.3g,yield 92.1percent, the target product without yellow block, long-term storage quality and stability., 14769-73-4

The synthetic route of 14769-73-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; lianyungangCity Yahui Pharmachem Co.,Ltd; Changzhou Yabang-QH Pharmachem Co., Ltd.; ZHU, JIANMIN; ZHANG, PINGHU; ZHANG, JIANFENG; LI, ZHILING; LIU, YONGLIN; (4 pag.)CN104230959; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

425392-45-6, Ethyl 5-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,425392-45-6

20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216 C.; 1H NMR (DMSO-d6) 7.69 (1H, s); 7.83 (1H, s); 9.05 (1H, s).

The synthetic route of 425392-45-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao; US2010/87448; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.

A solution of 5-amino-2-bromo-1 -butyl-1 H-imidazole-4- carboxamide (46 mg, 0.17 mmol), potassium te/t-butoxide (64 mg, 0.52 mmol), lithium bromide (76 mg, 0.8 mmol) and 7-chloro-benzothiazole-2-thiol (86 mg, 0.4 mmol) in 7 ml_ of DMF was stirred at 12O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 10percent) yielded 5-amino-1 -butyl-2- (7-chloro-benzothiazol-2-ylsulfanyl)-1 H-imidazole-4-carboxamide (33 mg, 49percent) as a foam. 1H-NMR [CDCI3, delta, ppm]: 7.73 (m, 1 H), 7.33 (m, 1 H), 7.26 (m, 1 H), 3.89 (m, 2H, CH2N), 1.54 (m, 2H, CH2), 1.37 (m, 2H, CH2), .0.92 (m, 3H, CH3). MS (El, m/z) 382 (M++1 ).

1849-73-6, 1849-73-6 7-Chlorobenzo[d]thiazole-2(3H)-thione 11171663, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

99073-88-8, Under nitrogen atmosphere, to a solution of this compound (4.00 g) in DMSO (100 mL)-CH3CN (100 mL) were added successively Pd(PPh3)4 (485 mg) and sodium formate (4.76 g), and the mixture was stirred at 100C for 75 minutes. The solvent was evaporated under reduced pressure, and thereto was added water, and the mixture was extracted four times with Et2O, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate = 10/1) to give ethyl 1,3-benzothiazole-6-carboxylate (1.21 g, 42 %). 1H NMR (CDCl3, 400MHz) delta 9.15 (s, 1H), 8.71 (dd, 1H, J=1.6, 0.5Hz), 8.21 (dd, 1H, J=8.6, 1.6Hz), 8.17 (dd, 1H, J=8.6, 0.5Hz), 4.44 (q, 2H, J=7.1Hz), 1.44 (t, 3H, J=7.1Hz).

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1479384; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64987-16-2,Methyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.

64987-16-2, A solution of 10 (1.044 g, 5.00 mmol) and Na2CO3 (0.530 g,5.00 mmol) in DMF (20 mL) was stirred at room temperature for 15 min. 2,2,2-Trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-one (1.852 g, 5.00 mmol) was added and mixture was stirred at 80 C overnight. Solvent was removed under reduced pressure, residue was suspended in ethyl acetate (60 mL) and successively washed with 10% citric acid (2 x 30 mL), saturated aqueous NaHCO3 solution (2 x 30 mL) and brine (30 mL), dried over Na2SO4, filtered and the solvent removed under reduced pressure. The crude product was recrystallized from methanol. Yield: 1.630 g (77.0%); white crystals; m.p. 200-202 C; IR (ATR) nu 3352, 3232, 3129, 2982, 1698, 1650, 1543, 1505, 1442, 1410, 1368, 1274,1218, 1172, 1116, 1085, 1010, 980, 886, 854, 823, 782, 729,687 cm-1; 1H NMR (400 MHz, DMSO-d6): delta 3.63 (s, 3H, CH3), 3.75 (s, 2H, CH2), 7.04 (s, 1H, thiazole-H), 7.45 (d, 1H, J = 2.6 Hz, pyrrole-H), 12.42 (s, 1H, NH), 13.12 (s, 1H, NH) ppm; 13C NMR (100 MHz, DMSO-d6): delta 36.4, 51.7, 98.8, 107.8, 110.8, 115.4, 125.8, 143.7, 156.6, 157.8, 170.5 ppm; HRMS (ESI-) m/z for C11H8N3O3SBr2 ([M-H]-): calcd 419.8653, found 419.8650; HPLC: method A, tr 13.09 min (95.4% at 254 nm).

The synthetic route of 64987-16-2 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Toma?i?, Tihomir; Mirt, Matic; Baran?okova, Michaela; Ila?, Janez; Zidar, Nace; Tammela, Paeivi; Kikelj, Danijel; Bioorganic and Medicinal Chemistry; vol. 25; 1; (2017); p. 338 – 349;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica