Day: March 22, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Route 1: To a suspension of N-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) (100 mg, 0.520 mmol) inTHF (5 mL) under Ar atmosphere were added 1-hydroxybenzotriazole(HOBt) (60 mg, 0.440 mmol) and the corresponding carboxylicacid (b-f) (0.400 mmol). After 30 min, 4-(benzo[e][1,2]azaborinin-2(1H)-ylmethoxy)-N-methylaniline (6) (106 mg, 0.400 mmol) followed by Et3N (121 mg, 167 lL, 1.20 mmol) were added at 0 Cand the mixture was allowed to warm to RT overnight (16 h). Thecrude mixture was then diluted with EtOAc (25 mL) and washedwith satd aq NH4Cl (3 25 mL) then brine (25 mL). The organicphase was isolated and dried over Na2SO4, filtered, and the solventwas removed in vacuo. The crude residue was further purified bygradient column chromatography (SiO2, flash, 0-100%EtOAc/heptane) to isolate the title compounds (2b-f) after solventremoval., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Vlasceanu, Alexandru; Jessing, Mikkel; Kilburn, John Paul; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4453 – 4461;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Part C Preparation of 5-thiazolemethanol To a solution of 11.73 g (82 mmol) of methyl 5-thiazolylcarboxylate in 105 mL of anhydrous tetrahydrofuran at 0 C. under nitrogen, was added 90 mL (90 mmol) of a 1.0M lithium aluminum hydride solution in diethyl ether over a 35 minute period. After stiiring at room temperature for 30 minutes, the solution was cooled to 0 C., and carefully quenched by the addition of 3 mL of water, 3 mL of 20% sodium hydroxide solution, and 6 mL of water, then 100 mL of tetrahydrofuran was added. After stirring for 1 hour, the mixture was filtered, the solid was washed with tetrahydrofuran, and the filtrate concentrated to afford 7.56 g of 5-thiazolylmethanol., 14527-44-7

As the paragraph descriping shows that 14527-44-7 is playing an increasingly important role.

Reference：
Patent; G. D. Searle & Co.; US5968942; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,943-03-3

Pyridine hydrochloride (1.18 g, 10.2 mmol, 10 eq) and 6-methoxy-2-cyanobenzothiazole (0.195 g, 1 .02 mmol, 1 eq) were combined in a rigorously dried sealed tube, purged and placed underan inert nitrogen atmosphere. The reaction mixture was then stirred at 180 00 for 1 h. The resulting red-brown residue was cooled to room temperature and then dissolved in EtOAc (20 mL) and washed with saturated NaHCO3 (1 x 20 mL), 1M HCI (1 x 10 mL), H20 (4 x 10 mL), and brine (1 x 1 0 mL). The organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The crude product was purified using column chromatography eluting with 3:7 EtOAc:Hexane to yield 2-cyano-6-hydroxybenzothiazole as a pale yellow solid. Mp: 202-207 0C (lit. 205-207 oc). 1H-NMR(400 MHz, DMSO) 510.51 (1H, brs, -OH), 7.89 (1H, d, J = 9.0 Hz, H-4), 7.60 (1H, d, J = 2.4 Hz,H-7), 7.19 (1H, dd, J = 9.1, 2.4 Hz, H-5) ppm. 13C-NMR (100.6 MHz, CDCI3) 5160.4(0-2), 147.4(C-6), 139.1 (C-3), 134.0 (0-8), 126.8 (C-7), 119.8 (C-5), 114.4 (C-i), 107.5 (C-4) ppm. MS(ESI+): m/z Calculated for C8H4N2OS [M+H] 177.0122, found 177.0117.

As the paragraph descriping shows that 943-03-3 is playing an increasingly important role.

Reference：
Patent; UNIVERSITY OF CAPE TOWN; JARDINE, Moegamat Anwar; RYLANDS, Marwaan; (60 pag.)WO2019/21202; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

209459-11-0, Methyl 2-aminobenzo[d]thiazole-7-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Isoamyl nitrite (22.0 mmol) is added to a solution of 2-amino-benzothiazole- 7-carboxylic acid methyl ester (10.1 mmol) in THF (29 mL). The mixture is heated to reflux for 4h, the solvents are removed in vacuo and the residue is purified by FC (gradient: heptane to EtO Ac/heptane 4/6) to give the desired product. LC-MS: tR = 0.85 min; [M+H]+ = 194.0., 209459-11-0

The synthetic route of 209459-11-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/16560; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 50D benzothiazole-6-carboxylic acid methyl ester To a 250 mL round bottom flask was added benzothiazole-6-carboxylic acid (5.0 g, 27.9 mmol), 100 mL methanol, and 10 mL thionyl chloride. The solution was refluxed 2 hours, cooled to ambient temperature, and concentrated under reduced pressure to provide the title compound. 1H-NMR (300 MHz, DMSO-d6) delta ppm 3.91 (s, 3H), 8.10 (dd, 1H), 8.19 (d, 1H), 8.86 (d, 1H), 9.60 (s, 1H); MS (ESI) m/z 194 [M+H]+.

3622-35-3, 3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz; US2005/209274; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

939-69-5, 6-Hydroxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

939-69-5, The mixture of 6-hydroxy-2-cyanobenzothiozole(0.311 g, 1.77 mmol), 3-chloropropyldimethylamine hydrochloride (0.36 g, 2.27 mmol), potassium carbonate (0.63g, 4.57 mmol) and sodium iodide (0.034 g) in acetone (30 ml) was heated to reflux overnight. Upon cooling to roomtemperature, the insoluble solid was removed by filtration. The compound was purified by flash chromatography usingmethylene chloride/methanol (96:4) as eluent in a yield of 86percent (0.387 g).1H NMR (CD2Cl2): 7.98 (d, J= 9.3 Hz, 1H), 7.32 (d, J= 2.4 Hz, 1H), 7.16 (dd, J = 9.0 Hz, J= 2.1 Hz, 1H), 4.04 (t, J = 6.4Hz, 2H, OCH2), 2.36 (t, J = 7.2 Hz, 2H, NCH2), 2.13 (s, 6H, CH3), 1.90 (m, 2H, CH2).

As the paragraph descriping shows that 939-69-5 is playing an increasingly important role.

Reference：
Patent; Promega Corporation; Cali, James J.; Daily, William; Hawkins, Erika; Klaubert, Dieter; Liu, Jianquan; Meisenheimer, Poncho; Scurria, Michael; Shultz, John W.; Unch, James; Wood, Keith V.; Zhou, Wenhui; Valley, Michael P.; (202 pag.)EP2277872; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

(a) To a solution of n-butyllithium (24 ml, 0.06 mol, 2.5M in hexane) in 50 ml of ether under argon at -78 C. was added dropwise a solution of 5-methylthiazole (5 g, 0.05 mol) in 25 ml of ether. The mixture was stirred at -78 C. for 1 h, and then a solution of N-formyl-morpholine (5.5 ml 0.055 mol) in 30 ml of ether was added within 15 min. The mixture was stirred for 1 h at -78 C., then at 0–5 C. overnight. The reaction mixture was then extracted with 4N HCl (4*10 ml), the aqueous layers were combined, cooled in an ice-bath, and neutralized with sodium bicarbonate solution (pH 9). The aqueous layer was extracted with ether (4*20 ml), the organic layer was dried over magnesium sulfate and concentrated in vacuo. The residue was dried in vacuo to afford 4.5 g (70.8%%) of 5-methyl-2-thiazolylcarboxaldehyde.

3581-89-3, As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.

Reference：
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Benzothiazole-6-carboxylic acid (6.00 g, 33.5 mmol) and 1-hydroxybenzotriazole (6.79 g, 50.2 mmol) were dissolved in N,N-dimethylformamide (500 mL, 6000 mmol). Then N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (9.63 g, 50.2 mmol) was added and the reaction was stirred at room temperature for 20 min. 4-(Methylamino)phenol sulphate (5.76 g, 16.7 mmol) was added followed by triethylamine (14.0 mL, 1.00E2 mmol). The reaction was stirred at room temperature for 5 days. The reaction mixture was evaporated and the residue was suspended in H2O (300 mL) and extracted with ethyl acetate (400 mL * 3). The combined organic phases were washed with sat. aq. NaHCO3 (300 mL), dried with magnesium sulfate, filtered and evaporated. The crude product was purified using Combiflash (Silica, Column Size 220 g, Eluent: heptane:ethyl acetate). Fractions containing the product were combined and evaporated to yield the intermediate N-(4-hydroxyphenyl)-N-methylbenzo[d]thiazole-6-carboxamide (26%) as light brown crystals. 1H NMR: (600 MHz, DMSO) delta 9.50 (s, 1H), 9.42 (s, 1H), 8.13 (br s, 1H), 7.89 (d, J = 8.2 Hz, 1H), 7.35 (br s, 1H), 7.00 (d, J = 8.2 Hz, 2H), 6.60 (d, J = 8.6 Hz, 2H), 3.34 (s, 3H). [M+H+]: 284.9.

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Article; Kilburn, John Paul; Kehler, Jan; Langgard, Morten; Erichsen, Mette N.; Leth-Petersen, Sebastian; Larsen, Mogens; Christoffersen, Claus Tornby; Nielsen, Jacob; Bioorganic and Medicinal Chemistry; vol. 21; 19; (2013); p. 6053 – 6062;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

STEP A: Preparation of benzothiazole-6-carboxylic acid (4-hydroxy-butyl)-amide (14A). 2.69 g (15 mmol) of benzothiazole-6-carboxylic acid is dissolved in a mixture of l.34 g (15 mmol) 4-amino-butan-l-ol and 70 mL dry tetrahydrofuran. 2.43 g (15 mmol) of CDI is added after stirring for 30 minutes and then stirred for another hour. The mixture is concentrated in vacuum. The resulting residue is suspended in dichloromethane, water is added, and the organic phase is separated. The aqueous phase is extracted with dichloromethane twice. The combined organic phases are dried over sodium sulfate and concentrated in vacuum. Yield: 55%; ESI-MS: 251 (M+H+)., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; MOTAC NEUROSCIENCE LIMITED; WO2009/56805; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The (4-formylphenyl)boronic acid 118 (0.30 g, 2.0 mmol), 2-bromo-1,3-thiazole 119a (0.33 g, 2.0 mmol), Pd(PPh3)4(0.12 g, 0.1 mmol), aqueous solution of potassium carbonate (0.4 M, 5 mL), ethanol (5 mL) and toluene (2 mL) were added to a 50 mL flask under nitrogen. The reaction mixture was stirred at 115 C. for 24 hours and then cooled to room temperature. After removing the solvent, the crude residue was purified by column chromatography on silica gel using EA/ hexane (1/5) as eluent. The product 120a was obtained as a white solid at a yield of 95%

3034-53-5, The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; National Health Research Institutes; Academia Sinica; Chen, Chih-Hao; Shih, Chuan; Chen, Chiung-Tong; Wang, Hwei-Jiung; Huang, Kai-Fa; US2020/71312; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica