With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.
(a) To a solution of n-butyllithium (24 ml, 0.06 mol, 2.5M in hexane) in 50 ml of ether under argon at -78 C. was added dropwise a solution of 5-methylthiazole (5 g, 0.05 mol) in 25 ml of ether. The mixture was stirred at -78 C. for 1 h, and then a solution of N-formyl-morpholine (5.5 ml 0.055 mol) in 30 ml of ether was added within 15 min. The mixture was stirred for 1 h at -78 C., then at 0–5 C. overnight. The reaction mixture was then extracted with 4N HCl (4*10 ml), the aqueous layers were combined, cooled in an ice-bath, and neutralized with sodium bicarbonate solution (pH 9). The aqueous layer was extracted with ether (4*20 ml), the organic layer was dried over magnesium sulfate and concentrated in vacuo. The residue was dried in vacuo to afford 4.5 g (70.8%%) of 5-methyl-2-thiazolylcarboxaldehyde.
3581-89-3, As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.
Reference：
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica