14190-59-1, Thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
14190-59-1, Compound 1 (3 mmol), compound 2 (3 mmol), N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) (3.3 mmol) and N,N-dimethylpyridine (DMAP) (0.3 mmol) were mixed with a molecular sieve, and the resulted mixture was cooled in ice bath (0° C.). Then DMF and pyridine (4.5 mmol) were added in turn. The progress of reaction was tracked by TLC. After the reaction was completed, the reactant was diluted with water and extracted with EtOAc. The solvent was removed completely by concentration. Then compound 3 was obtained through column chromatograph (yield 60percent). Subsequently, compound 3 (0.3 mmol) was mixed with ammonium acetate (NH4OAc) (15 mmol) and sodium acetate (NaOAc) (30 mmol) and heated to 130° C., and the progress of reaction was tracked by TLC. Then the reactant was cooled to room temperature, and diluted with water, extracted with ethyl acetate. The solvent was removed completely by concentration. Then compound 4i (Wang279-1) was obtained by separation through column chromatograph with petroleum ether/ethyl acetate (volume ratio 1:1) (yield 31percent).
The synthetic route of 14190-59-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; US2008/306121; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica