With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133692-16-7,2-Amino-5-bromo-4-methylthiazole hydrochloride,as a common compound, the synthetic route is as follows.
EXAMPLE 65 A mixture of 2-amino-5-bromo-4-methylthiazole hydrochloride (4.5 g), 2-mercaptopyridine (2.3 g) and potassium carbonate (7.0 g) in N,N-dimethylformamide (100 ml) was heated at 90 C. for 3 hours with stirring. The reaction mixture was concentrated under reduced pressure and water was added to this residue. The mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate, washed with aqueous saturated sodium chloride and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give solid. The solid was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 300 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give oil. Again the oil was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 200 g) and eluted with a mixture of dichloromethane and acetone (5:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give 2-amino-4-methyl-5-(2-pyridylthio)thiazole (2.1 g, yield: 47.9%). NMR (DMSO-d6, 200 MHZ, ppm): 2.13 (3H, s), 6.97 (1H, m), 7.15 (1H, m), 7.28 (2H, s), 7.65 (1H, m), 8.40 (1H, m) Mass: M+1 224, M 223, m/e 208, 190, 181, 145, 111
133692-16-7, The synthetic route of 133692-16-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5256675; (1993); A;,
Thiazole | C3H3NS – PubChem
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