With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4146-24-1,6-Chloro-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,4146-24-1
Step (iv): 2-(Bromomethyl)-6-chloro-l,3-benzothiazole To the solution of 6-chloro-2-methyl-l,3-benzothiazole (15 g, 81.96 mmol) in carbon tetrachloride (500 ml) was added benzoyl peroxide (0.92 g, 0.364 mmol) and N- bromosuccinimide (18.52 g, 10.40 mmol) and the resulting mixture was stirred at reflux for 14 hours. Upon cooling the mixture was filtered through a “Celite” bed, washed with dichloromethane and the solvent was evaporated in vacuo to obtain crude product.The crude compound was purified by column chromatography (silica, 0-5 % ethyl acetate in ft-hexane) to afford the title compound.1H NMR (DMSO-i) delta ppm 5.14 (s, 2 H), 7.58-7.61 (d, 1 H), 8.01-8.03 (d, 1 H), 8.3 (s, 1 H)
4146-24-1 6-Chloro-2-methylbenzo[d]thiazole 138133, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica