1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 3-necked round bottomed flask, containing a magnetic stirrer, 32 mg (0.7 mmol) of [3-(5-amino-2-bromo-4-carbamoyl-imidazol-1 -yl)-propyl]-isopropyl- carbamic acid tert-butyl ester, 34 mg (0.4 mmol) of LiBr, 22 mg (0.17 mmol) of potassium te/t-butoxide and 28 mg (0.14 mmol) of 7-chloro-benzothiazole-2- thiol were weighted. The flask was purged with argon and 6 ml_ of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CbZMeOH: 96/4) affording the 3-[5-amino-4-carbamoyl-2-(7-chloro-benzothiazol-2-ylsulfanyl)- imidazol-1-yl]-propyl}-isopropyl-carbamic acid tert-butyl ester compound (14 mg, 34percent) as a foam. 1H-NMR [ CD3OD, delta, ppm]: 7.77 (m, 1 H), 7.38 (m, 1 H), 7.28 (m, 1 H), 4.00 (m, 2H), 3.10 (m, 1 H), 1.90 (m, 4H), 1.42 (s, 9H), 1.01-1.04 (2s, 6H)., 1849-73-6
The synthetic route of 1849-73-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
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