40283-41-8,40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of ethyl 2-aminothiazole-4-carboxylate (4.56 g) in THF (200 ml), 1M aqueous solution of sodium hydroxide (30 ml) was added and the mixture was stirred at room temperature for 3 hours. The reaction solution was combined with 1M hydrochloric acid (30 ml), concentrated, and the resultant residue was dissolved in DMF (50 ml). Then, 6-chloropyridazin-3-ylhydrazine (3.83 g) and WSCD hydrochloride (6.09 g) were added, and the mixture was stirred at room temperature. The reaction solution was combined with water, and the precipitate was collected by filtration, and washed with water and diethyl ether, combined with acetic acid (30 ml), heated under reflux, and then the reaction solution was concentrated under reduced pressure. The residue was combined with saturated aqueous solution of sodium hydrogen carbonate, and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. To this, piperidine (10 ml) was added and the mixture was heated at 100C, and the reaction solution was concentrated under reduced pressure, and the resultant residue was purified by silica gel column chromatography (eluent: chloroform_methanol=30:1) to obtain 3-(2-aminothiazol-4-yl)-6-(piperidin-1-yl)-1,2,4-triazolo[4,3-b]pyridazine (0.92 g) as yellow solids.
40283-41-8 2-Aminothiazole-4-carboxylic acid 1501882, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1481977; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica