Day: March 24, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14190-59-1,Thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Compound 1 (3mmol), compound 2 (3mmol), N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) (3.3mmol) and N,N-dimethyl pyridine (DMAP) (0.3mmol) were mixed with a molecular sieve, and the resulted mixture was cooled in ice bath (0°C). Then DMF and pyridine (4.5mmol) were added in turn. The progress of reaction was tracked by TLC. After the reaction was completed, the reactant was diluted with water and extracted with EtOAc. The solvent was removed completely by concentration. Then compound 3 was obtained through column chromatograph (yield 60percent). Subsequently, compound 3 (0.3mmol) was mixed with ammonium acetate (NH4OAc) (15mmol) and sodium acetate (NaOAc) (30mmol) and heated to 130°C, and the progress of reaction was tracked by TLC. Then the reactant was cooled to room temperature, and diluted with water, extracted with ethyl acetate. The solvent was removed completely by concentration. Then compound 4i (Wang279-1) was obtained by separation through column chromatograph with petroleum ether/ ethyl acetate (volume ratio 1:1) (yield 31percent).

14190-59-1, 14190-59-1 Thiazole-2-carboxylic acid 2762733, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; EP1889843; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

118452-02-1, 2-Aminothiazole-4-carboxamide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4. g (28 mmol) 2-Aminothiazol-4-carboxamide was dissolved in 40 ml glacial acetic acid, to which added 2.8 ml (29.6 mmol) acetic anhydride, followed by reacting under reflux for 2 hr, and naturally cooling down to precipitate a large quantity of solids, which were filtered, washed and dried to obtain 4.7 g 2-acetylaminothiazol-4-carboxamide (yield 92%) with mp >250C., 118452-02-1

The synthetic route of 118452-02-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. 2-Formylthiazole To a cooled solution (-95° C.) of t-butyllithium (1.7M in pentane, 17.9 mL, 30.5 mmol, 2.0 eq) in tetrahydrofuran (150 mL) under nitrogen was added 2-bromothiazole (2.50 g, 15.3 mmol). The resulting suspension was stirred below -80° C. for 45 min The lithiated thiazole solution was transferred via cannula to a solution of dimethylformamide (1.42 mL) in tetrahydrofuran (100 mL) at -90° C. The reaction was allowed to warm to room temperature over 2 h and quenched by the addition of water (100 mL). The aqueous phase was extracted with ethyl acetate (3*75 mL). Combined organic extracts were dried over anhydrous magnesium sulfate, filtered and reduced to a crude oil in 87percent yield. TLC analysis (Rf 0.50, 40percent ethyl acetate in hexane). No further characterization was undertaken; the crude title compound was taken on to the sodium borohydride reduction.

3034-53-5, As the paragraph descriping shows that 3034-53-5 is playing an increasingly important role.

Reference：
Patent; Zeneca Limited; US5512575; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-6-(trifluoromethyl)benzo[d]oxazole (500 mg, 2.26mmol) in DMF (8.0 mL) were added 2-aminothiazole-4-carboxamide (323mg, 2.26mmol) and K2003 (937mg, 6.78mmol) . The resulting mixture was stirred at 100 00 for 3 h. TLC showed the reaction to be complete. The reaction mixture was poured in to ice water (5OmL). The solid precipitated was filtered and washed with water (5OmL) and dried by azeotropic distillation using toluene. Thus obtained solid was triturated with DCM (lOmL) followed by Et20 (lOmL) and dried under vacuum. The solid was further purified by prep HPLC to afford 2-((6-(trifluoromethyl)benzo[d]oxazol-2- yl)amino)thiazole-4-carboxamide as an off white solid. Yield: 30mg (4.0%); MS (ESl+) for CHNOS m/z 328.99 [M+H] LC purity 98.0 % (Ret. Time- 5.55 mm); 1H NMR (400 MHz, DMSO-d6): 13.02 (5, 1H), 7.96 (5, 1H), 7.88 (bs, 1H), 7.78 (5, 1H), 7.58-7.73 (m, 3H).

118452-02-1, The synthetic route of 118452-02-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

96929-05-4, a) Boc-2-Aminomethylthiazole-4-carboxamide; [00073] At 10 C., ethyl bromopyruvate (386 g, 1.98 mol) was added dropwise to a solution of Boc-glycinethioamide (370 g, 1.94 mol) in 3.9 liters of ethanol, and the mixture was then stirred at 20-25 C. for 5 h, after which 299 ml of a 25% strength aqueous ammonia solution were added. [00074] From 940 ml of this mixture (corresponds to 19.9% of the total volume), 380 ml of ethanol were distilled off, a further 908 ml of a 25% strength aqueous ammonia solution were added and the mixture was stirred at 20-25 C. for 110 h. The mixture was cooled to 0 C. and the solid was filtered off, washed twice with water and dried. This gave 60.1 g of the BOC-protected thiazole carboxamide of an HPLC purity of 97.9 area %, which corresponded to a yield over these two steps of 60.5%. [00075] 1H-NMR (DMSO-d6, in ppm): 8.16 (s, 1H, Ar-H), 7.86 (t, broad, 1H, NH), 7.71 and 7.59 (2×s, broad, 1H each, NH2), 4.42 (d, 2H, CH2), 1.41 (s, 9H, tert-butyl).

The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Abbott GmbH & Co. KG; US6642388; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Carboxylic acids (1 mmol) and 1,1′-carbonyl diimidazole(1 mmol) were taken in THF (15 mL) in a round-bottommed flask(100 mL) and stirred for 30 min in order to activate the carboxylicacids. Then metronidazole (1 mmol) was added into the reactionmixture with constant stirring for 24 h. Reaction progress wasmonitored by TLC (6:4 EtOAc:Hexane). Reaction mixture waspoured onto crushed ice (100 mL), precipitates appeared immediatelywhich were filtered and dried in air. The precipitates werecrystallized from ethanol. Products were characterized by spectroscopictechniques such as EIMS, 1H NMR and 13C NMR. CHNanalysis was also performed.

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Article; Salar, Uzma; Khan, Khalid Mohammed; Taha, Muhammad; Ismail, Nor Hadiani; Ali, Basharat; Qurat-ul-Ain; Perveen, Shahnaz; Ghufran, Mehreen; Wadood, Abdul; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1289 – 1299;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

6294-52-6, 5,6-Dimethoxybenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6294-52-6

General procedure: Chloroacetyl chloride(33 mmol, 2.63 mL) was added dropwise with stirring to a mixtureof triethylamine (33 mmol, 4.63 mL) and 2-aminobenzothiazole oraniline derivative (30 mmol) in THF (100 mL) at 0 C. After thecompletion of dropping, the mixturewas allowed to stir for 1 h. Thesolvent was evaporated under reduced pressure. The residue waswashed with water to remove trimethylamine hydrochloride, driedand recrystallized from EtOH [59,60].

The synthetic route of 6294-52-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Sa?l?k, Beguem Nurpelin; Ilg?n, Sinem; Oezkay, Yusuf; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 1026 – 1040;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182344-56-5,2-Chloro-4-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 162 (+)-(4aR)-(10bR)-4-methyl-8-(4-fluoro-2-benzothiazolylthio)-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one A 15 mL round bottom flask was charged with (+)-(4aR)-(10bR)-4-methyl-8-mercapto-10b-methyl-1,2,3,4,4a,-5,6,10b-octahydrobenzo[f]quinolin-3-one (100 mg, 0.38 mmol), potassium carbonate (158 mg, 1.14 mmol), 2-chloro-4-fluorobenzothiazole (86 mg, 0.46 mmol and 1 mL of anhydrous dimethylformamide, fitted with a reflux condenser, and the stirred mixture was heated at 60, under nitrogen, for 48 h. The mixture was cooled, diluted with ethyl acetate (75 mL) and washed with brine (2*25 mL). The combined organic extracts were dried over sodium sulfate, concentrated, and purified by silica gel chromatography (80% ethyl acetate/hexanes eluent) to give 91 mg (58%) of the title compound as an amorphous solid. mp 140-145. FDMS: m/e=412. alpha[D]589 =+70.06 (c=0.52, chloroform)., 182344-56-5

182344-56-5 2-Chloro-4-fluorobenzo[d]thiazole 2049864, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Eli Lilly and Company; US5550134; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Preparation Example 17; Preparation of Compound (17); Under argon atmosphere, 2-amino-6-bromobenzothiazole (20 g, 87.3 mmol) and 10 N KOH (100 mL) were added to ethylene glycol (20 mL), and the mixture was stirred at 125 C. under reflux for 15 hours. After cooling to room temperature, 12 N HCl (30 mL) was added to the reaction mixture to quench the reaction. The reaction mixture was then washed with water (100 mL) and extracted with EA (100 mL). Recrystallization from MeOH (200 mL) gave 2-amino-5-bromobenzenethiol (14 g, 68.6 mmol, 79%).In 1,4-dioxane (35 mL, 2.0 M), dissolved were 2-amino-5-bromobenzenethiol (14 g, 68.6 mmol) and salicylaldehyde (7.0 g, 57.2 mmol), and the solution was stirred at 100 C. under pressure for 12 hours. After cooling to room temperature, the reaction mixture was extracted with MC (150 mL), washed with water (100 mL) and dried under reduced pressure. Purification via silica gel column chromatography (n-hexane: MC=5:2) gave 2-(6-bromobenzo[d]thiazol-2-yl) phenol (15.5 g, 50.5 mmol, 88.3%).Under argon atmosphere, 2-(6-bromobenzo[d]thiazol-2-yl)phenol (15.5 g, 50.5 mmol) was dissolved in THF (160 mL, 0.3 M), and the solution was cooled to -78 C. To the solution, t-BuLi (1.7 M in hexane, 44.6 mL, 75.8 mmol) was added dropwise, and the mixture was stirred for 30 minutes. Triphenylsilyl chloride (TPSCl) (22.3 g, 75.8 mmol) dissolved in THF (50 mL) was slowly added thereto. The reaction mixture was stirred for 12 hours while slowly raising the temperature to room temperature. After quenching the reaction by adding water (100 mL), the reaction mixture was extracted with MC (80 mL). Drying under reduced pressure and purification via silica gel column chromatography (n-hexane: MC=3:1) gave 2-(6-triphenylsilylbenzo[d]thiazol-2-yl)phenol (20.4 g, 42 mmol, 83%).Compound (17) (1.0 g, 0.72 mmol, 45%) was obtained by repeating the same procedure as described in Preparation Example 1, but using 2-(6-triphenylsilylbenzo[d]thiazol-2-yl)phenol (2.0 g, 4.1 mmol), ZnCl2 (375 mg, 2.7 mmol), EtOH (70 mL, 0.02 M), NH4OH (2.0 mL) and water (20 mL).mp. >300 C.1H NMR (300 MHz, CDCl3): d=8.40-8.34 (m, 2H), 7.83-7.55 (m, 7H), 7.35 (s, 9H), 7.31 (d, J=5.1 Hz, 1H), 7.0-6.7 (m, 3H)MS/FAB: 1580.22 (found), 1584.77 (calculated), 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Gracel Display Inc.; US2010/152455; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19989-67-4,Benzo[d]thiazole-6-carbaldehyde,as a common compound, the synthetic route is as follows.

To a mixture of compound B-184 (2.5 g, 15 mmol) in 50% ethanol/water (20 mL) was added hydroxylamine hydrochloride (2.1 g, 30 mmol) and potassium carbonate (4.2 g, 30 mmol) at room temperature. The mixture was stirred at room temperature overnight. On completion, the reaction was filtered, and the resulting filtrate was concentrated in vacuo and purified by silica gel column chromatography [petroleum ether : ethyl acetate = 20: 1] to give compound B-185 (2.3 g, 84% yield) as a white solid., 19989-67-4

The synthetic route of 19989-67-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica