40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a reaction flask equipped with a stirrer, a condenser and a thermometer, 7.4 g of propionic acid was added, and 100 mL of dichloromethane was further added. Add EDC · HCl19.2g, then add 16g of triethylamine, stirring at room temperature for some time, adding DMAP1.5g, stirring for some time,Then, 45.8 g of oleanolic acid was added, and the reaction was stirred at room temperature. TLC was used to control the progress of the reaction.After the completion of the reaction, an appropriate amount of EDC · HCl (15.4 g) and triethylamine (12.8 g)After stirring for a while at room temperature, 14.4 g of 2-amino-4-carboxythiazole was added and the reaction was continued at room temperature. TLC controlled the progress of the reaction. After completion of the reaction, the reaction solution was washed with 3 x 100 mL of dilute hydrochloric acid aqueous solution and then washed with 3 x 100 mL of saturated brine, dried, evaporated to dryness, and purified by ethyl acetate-petroleum ether to give 43.8 g of a white solid product(HPLC: 99.5%), Rf = 0.21 [single point, developing solvent: v (petroleum ether): v (ethyl acetate) = 4: 1]The total yield was 68.5%
40283-41-8, The synthetic route of 40283-41-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Tianjin Institute of pharmaceutical research; Liu, Ying; Liu, DengKe; Zhang, Dashuai; Niu, Duan; Wu, jiang; Zou, meixiang; (7 pag.)CN103265607; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica