With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
A mixture of 2-bromo-5-(4-methoxybenzyloxy)pyridine (1 .10 g), methyl thiazole-5- carboxylate (644 mg), Pd(P(f-Bu)3)2 (153 mg), Cs2CO3 (1 .20 g) and DMF (10 mL) was evacuated and refilled with nitrogen three times. The mixture was stirred at 150C under N2 atmosphere for 3 hours. Insoluble material was removed by filtration through Celite. The filtrate was diluted with H2O (100 mL). The solid obtained was collected by filtration and washed with MeOH to provide the subtitle compound. MS ESI+: m/z = 357 [M+H]+.
14527-44-7, 14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica