With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
A solution of FeSO4·7H2O (33.4 g, 120 mmol) in 80 ml H2O and 70% tert-butyl hydroperoxide (12 ml, 120 mmol) were added to a stirred and cooled (10-20 ) mixture of the methyl-thiazole-5-carboxylate 6 (2.86 g, 20 mmol), 4 M H2SO4 (10 ml), and the 40% aldehyde (13.22 g, 120 mmol) separately and simultaneously. The reaction mixture was stirred at room temperature (25 ) for 1 h, extracted with EtOAc and washed with saturated Na2S2O3 solution and brine. After drying over anhydrous Na2SO4 and removing the solvent, a crude material was obtained. The material was purified by column chromatography (PE:EtOAc, 50:1, v/v) to afford compound 7 (2.97 g, 80%) as pale yellow solid. MS (ESI) m/z 186.0 [M+H]+. 1H NMR (400 Hz, CDCl3) delta 8.50 (s, 1H), 3.95 (s, 3H), 2.73 (s, 3H) ., 14527-44-7
The synthetic route of 14527-44-7 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Chang, Shaohua; Zhang, Zhang; Zhuang, Xiaoxi; Luo, Jinfeng; Cao, Xianwen; Li, Honglin; Tu, Zhengchao; Lu, Xiaoyun; Ren, Xiaomei; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1208 – 1212;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica