With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.
[00181] A solution of 6-(trifluoromethyl)benzo[d]thiazole (3) (830 mg, 4.08 mmol) and hydrazine monohydrate (1.52 g, 30.6 mmol) in ethanol (20 mL) was heated to reflux for 1.5 h. The mixture was added to a solution of acetic acid (3 mL) in water (100 mL) and extracted with DCM. The organic extract was dried over Na2S04and concentrated under reduced pressure. The crude material was purified by silica gel chromatography to afford 670 mg (84%) of the title compound as a yellow oil. NMR (400 MHz, CDCI3) delta 7.62 (d, J= 1.2 Hz, 1H), 7.39 (dd, J = 8.4, 2.0 Hz, 1H), 6.75 (d, J= 8.4 Hz, 1H), 4.49 (s, 2H), 2.95 (s, 1H).
131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOGRA PHARMA LIMITED; VITI, Francesca; BELLINVIA, Salvatore; DEMARTIS, Salvatore; (104 pag.)WO2015/197861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica