With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.
3034-53-5, To a reaction flask were added a solution of n-butyl lithium in cyclohexane (60 mL,150 mmol, 2.5 mol/L) and anhydrous ethyl ether (100 mL). The mixture was stirred at -78 ocunder nitrogen protection, then 2-bromothiazole (20 g, 122 mmol) was added dropwise slowlyinto the mixture for 1 h. The mixture was heated to 70 oc and stirred for 30 min, then DMF(14.26 g, 195 mmol) was added for 1 h. The mixture was cooled to -40 oc and stirred for 1 h.The reaction mixture was warmed to 0 oc and to the reaction mixture was added HCl (4 M) (100mL), and the resulting mixture was partitioned. The aqueous layer was adjusted with saturatedaqueous potassium carbonte to pH about 7 to 8. The mixture was extracted with ethyl ether (100mL x 3). The combined organic layers were washed with saturated brine (100 mL), dried overanhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give the titlecompound as brownish red oil (7 .0 g, 51 percent ).MS (ESI, pos. ion) m/z: 114.1 [M+Ht.
The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica