Day: March 24, 2022

6294-52-6, 5,6-Dimethoxybenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6294-52-6, 2-Chloro-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)acetamide (Compound 53) To the reaction mixture of 5,6-dimethoxybenzo[d]thiazol-2-amine (50 mg, 0.238 mmol), TEA (0.100 mL, 0.713 mmol) in DCM (1 mL) was added 2-chloroacetyl chloride (0.023 mL, 0.285 mmol) at room temperature. Overnight, concentration and purification on combiflash (4 g, MeOH/DCM) gave 2-chloro-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)acetamide (15 mg, 0.052 mmol, 22.00% yield). 1HNMR (400 MHz, CDCl3), 9.73 (s, 1H), 7.26 (s, 1H), 7.25 (s, 1H), 4.30 (s, 2H), 3.969s, 6H) ESI-MS: m/z 286.94 (M+H)+

6294-52-6 5,6-Dimethoxybenzo[d]thiazol-2-amine 94938, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Stingray Therapeutics, Inc.; The University of Utah; Vankayalapati, Hariprasad; Liu, Xiaohui; Ramamoorthy, Gurusankar; Sharma, Sunil; Kaadige, Mohan Rao; Weston, Alexis; Thode, Trason; (59 pag.)US2019/31655; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

939-69-5, 6-Hydroxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

939-69-5, To the solution of benzene sulfonyl chloride derivative (0.7 g, 2.98 mmol) and 2-cyano-6-hydroxoylbenzothiazole or 2-cyano-6-hydroxyquinoline (2.84 mmol) in 10 ml of dry methylene chloride, triethylamine (0.58 g, 5.68 mmol) at room temperature was added, and the resultant mixture stirred for 3 hours. The product was purified by flash chromatography using heptane/methylene chloride (1/2) as eluent. (yield 85percent): 1H NMR (CDCl3) delta(ppm): 8.30 (d, J= 2.0 Hz, 1H), 8.16 (d, J= 9.3 Hz, 1H), 8.13 (dd, J = 8.7 Hz, J= 2.0 Hz, 1H), 8.04 (d, J = 8.7 Hz, 1H), 7.78 (d, J = 2.4 Hz, 1H), 7.27 (dd, J = 9.0 Hz, J = 2.4 Hz, 1H), 2.95 (s, 3H, CH3). MS (ES) m/e (M+1): 376.

939-69-5 6-Hydroxybenzo[d]thiazole-2-carbonitrile 9881912, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Promega Corporation; HUANG, Fen; KLAUBERT, Dieter; SHULTZ, John; ZHOU, Wenhui; (54 pag.)EP2611929; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-(3-fluorobenzyloxy)-benzylamine described in Preparation Example 6 (129mg, 0.558mmol) and benzothiazole-6-carboxylic acid (100mg, 0.558mmol) in tetrahydrofuran (5mL) were added benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (296mg, 0.670mmol) and triethylamine (93mul, 0.670mmol), and the solution was stirred overnight at room temperature. Ethyl acetate and water were added to the reaction solution, which was then partitioned, the organic layer was washed with water, and then, dried over anhydrous magnesium sulfate. The solvent was evaporated, the residue was purified by NH silica gel column chromatography (hexane : ethyl acetate), and the title compound (148mg, 68%) was obtained as a white solid. 1H-NMR Spectrum (CDCl3) 6(ppm) : 4.64(2H, d, J=5.6Hz), 5.08(2H, s), 6.42(1H, brs), 6.97(2H, d, J=8.8Hz), 7.02(1H, td, J=2.8, 8.4Hz), 7.15-7.21 (2H, m), 7.31-7.38(3H, m), 7.88(1H, dd, J=1.6Hz, 8.4Hz), 8.17(1H, d, J=8.8Hz), 8.50(1 H, d, J=1.6Hz), 9.12(1 H, s).

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: tert-butyl (2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-ylcarbamate (6) (31.0 g) in dichloromethane was added to a solution of benzothiazole-6-carboxylic acid (1.05 eq), triethylamine (1.5 eq) and HATU (2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, 1.05 eq) in dichloromethane (500 mL). The reaction mixture was stirred at room temperature overnight. Water was added and the phases were separated. The organic phase was three times washed with a saturated aqueous Na2CO3 solution, brine, dried with MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: dichloromethane dichloromethane / methanol 95:5) to afford compound 8 quantitative., 3622-35-3

As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Article; Jonckers, Tim H.M.; Rouan, Marie-Claude; Hache, Geerwin; Schepens, Wim; Hallenberger, Sabine; Baumeister, Judith; Sasaki, Jennifer C.; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 4998 – 5002;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188937-16-8,2-(2-Thiazolyl)acetic Acid,as a common compound, the synthetic route is as follows.

To a solution of 5-bromo-4- (4-fluorophenyl) -6-hydrazinylpyrimidin-2-amine (400 mg, 1.3 mmol), 2- (1, 3-thiazol-2-yl) acetic acid (384 mg, 2.7 mmol), TEA (543 mg, 5.4 mmol) in DMSO (10 mL) was added HATU (1.3 g, 3.4 mmol). Stirred at 25C for 4 hours. The resulting mixture was poured into 100 mL water and filtered. The solid was dried in vacuum to afford N- [2-amino-5-bromo-6- (4-fluorophenyl) pyrimidin-4-yl]-2-(1, 3-thiazol-2-yl) acetohydrazide (336 mg, 59%) as a dark-grey solid. LCMS: m/z (ESI), [M+H] + = 423, 4. 1H NMR (300 MHz, DMSO-d 6) delta 4.05 (s, 2H), 6.42 (s, 2H), 7.28 (t, 2H), 7.54-7.70 (m, 3H), 7.75 (d, 1H), 8.75 (s, 1H), 10.22 (s, 1H)., 188937-16-8

The synthetic route of 188937-16-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; ZENG, Qingbei; QI, Changhe; TSUI, Honchung; YANG, Zhenfan; ZHANG, Xiaolin; (206 pag.)WO2020/52631; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

As shown in step 2-i of Scheme 2, 6-Bromobenzo[hours and then cooled to room temperature. Water (300 mL) was added and the reaction mixture was stirred for 1 hour. The resulting precipitate was collected by filtration, washed twice with water, and dried to produce lambda/-(6-bromobenzo[15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2009/129211; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Iso-Pentyl nitrite (0.9 mL, 6.8 mmol) and copper (II) chloride (0.938 g, 5.5 mmol) were suspended in CH3CN (25 mL), and the mixture was stirred at 65 C. for 30 min. A solution of 6-bromobenzo[d]thiazol-2-amine (I-2) (1 g, 4.37 mmol) in THF (20 mL) was added dropwise, and the resulting mixture was stirred at 85 C. for 1 h. The mixture was allowed to cool to RT, poured into 20% HCl (200 mL), filtered, and the cake was washed with water (50 mL). The crude product was purified by flash column chromatography on silica gel (200-300 mesh) eluting with petroether/ethyl acetate (40/1) to give the desired product, 6-bromo-2-chlorobenzo[d]thiazole (701) (0.58 g, 53.7% yield) as a pale solid. ESI-MS (M+H)+m/z: 247.9.

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Intellikine LLC; Ren, Pingda; Liu, Yi; Wilson, Troy Edward; Li, Liansheng; Chan, Katrina; US2015/225407; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42270-37-1, 2-(Piperazin-1-yl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6.11. Preparation of (3′-Chloro-biphenyl-4-yl)-(4-thiazol-2-yl-piperazin-1-yl)-methanone To a solution of 1-(thiazol-2-yl)piperazine (ca. 0.915 mmol, prepared from 150 mg 2-bromothiazole according to the methods described in Astles et al., J. Med. Chem., 39: 1423-1432 (1996)), 3′-chloro-biphenyl-4-carboxylic acid (212.9 mg, 0.915 mmol) in CH2Cl2 (4 ml), was added EDC (209.7 mg, 1.098 mmol) and HOBt (148.2 mg, 1.098 mmol). Aflter being stirred overnight, the mixture was treated with EtOAc (50 ml) and water (15 ml). The organic phase was washed with brine (5 ml), dried (MgSO4), filtered, and concentrated under reduced pressure to furnish the crude product. This material was purified by column chromatography (20% acetone/hexanes) to give the title compound (225 mg, 64% for two steps) as a white solid: 1H NMR (CDCl3, 400 MHz) delta 7.64-7.23 (m, 9 H), 6.65 (t, J=3.6 Hz, 1 H), 4.92 (m, br, 2 H), 3.57 (m, br, 6 H), 3.68 (m, 2 H), 2.14 (m, 2 H), 1.83 (m, 2 H); MS calc’d for C20H19ClN3OS [M+H]+: 384; Found: 384., 42270-37-1

The synthetic route of 42270-37-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Barbosa, Joseph; Dong, Li; Fink, Cynthia Anne; Wang, Jiancheng; Zipp, G. Gregory; US2006/258672; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Add 5 g of 2-amino-6-bromo-benzothiazole to 25 mL of a 10 M potassium hydroxide solution. Adding a mixed solution of 5 mL of ethylene glycol and stirring the reaction at 125 C for 2 h. Obtaining 2-amino-5-bromobenzenethiol, 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Nanjing Zhongpengliankang Medical Treatment Technology Co., Ltd.; Liu Yuanhao; (18 pag.)CN108239101; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 48 STR131 Compound 48 was prepared using the method of Example 12. Benzothiazole replaced benzothiazole-6-carboxylic acid in step a and N-Boc-L-proline replaced N-CBZ-N-methyl-D-phenylalanyl-L-proline in step d to give the title compound as a solid: FAB-MS m/z 389 (MH+); Anal. Calc’d for C18 H24 N6 O2 S*1.9 CF3 CO2H*0.9 H2 O: Calculated C, 42.14; F, 17.43; H, 4.49; N, 13.53, H2 O, 2.58 Found: C, 42.30; F, 17.69; H, 4.20; N, 13.18, H2 O, 2.61 EXAMPLE 49 STR132 Compound 49 was prepared by the method of Example 12. Benzo[b]thiophene replaced benzothiazole-6-carboxylic acid in step a and the remaining steps in the sequence were carried out with only minor modifications to give the title compound as a solid: [alpha]D25 =-78.3 (C=1.00, MeOH); FAB-MS m/z 549 (MH+);

3622-35-3, 3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Costanzo; Michael J.; Maryanoff; Bruce E.; US5523308; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica