Day: March 24, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 2-bromo-5-(4-methoxybenzyloxy)pyridine (1 .10 g), methyl thiazole-5- carboxylate (644 mg), Pd(P(f-Bu)3)2 (153 mg), Cs2CO3 (1 .20 g) and DMF (10 mL) was evacuated and refilled with nitrogen three times. The mixture was stirred at 150C under N2 atmosphere for 3 hours. Insoluble material was removed by filtration through Celite. The filtrate was diluted with H2O (100 mL). The solid obtained was collected by filtration and washed with MeOH to provide the subtitle compound. MS ESI+: m/z = 357 [M+H]+.

14527-44-7, 14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1) Formation of tert-butyl (6-bromo-1 ,3-benzothiazol-2-yl) carbamate2-Amino-6-bromobenzothiazole (2.0 g; 8.7 mmol) was suspended in DCM (40 ml.) to which were added di-te/f-butyl dicarbonate (2.86 g; 13.1 mmol) and DMAP (4 mg; 0.03 mmol). The resulting mixture was stirred at RT for 16 h then concentrated in vacuo. The residue was suspended in 2M NH3 in MeOH and stirred at RT for 2 h then concentrated in vacuo. The residue was triturated in water and filtered to afford the title compound (2.64 g, 92%) as a white solid. 1H NMR (DMSOd6, 300 MHz) delta 1 1.86 (s, 1 H), 8.19 (d, J = 2.0 Hz, 1 H), 7.60 (d, J = 8.5 Hz, 1 H), 7.52 (dd, J = 2.0, 8.5 Hz, 1 H), 1.51 (s, 9H).

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Example 10; Preparation of 7V-(6-Phenylbenzo[15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng; WO2010/8847; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-55-3, Benzo[d]thiazol-7-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1123-55-3, A mixture of 1, 3-BENZOTHIAZOL-7-AMINE (Description 43,30 mg, 0.2 mmol) and [4- (trifluoromethyl) benzyl] isocyanate (Description 3,40 mg, 0.2 mmol) in DCM (2 ml) was stirred at room temperature for 18 h. TLC analysis showed minimal reaction therefore 1,2-dichloroethane (1 ml) was added and the mixture was heated at 80C for 4 h. N, N-DIMETHYLFOM-LAMIDE (0.25 ml) was then added and the mixture was heated at 80C for 18 h. The mixture was then cooled to room temperature and stirred at this temperature for 2 h. The mixture was filtered to give the title compound as a white solid (28 mg, 40%). 1H NMR (d6 DMSO, 400 MHz) 8 9.33 (1H, s), 8.74 (1H, s), 7.82 (1H, d, J7. 9), 7.73 (3H, m), 7.55 (2H, d, J 8. 0), 7.45 (1H, t, J 8. 0), 7.10 (1H, br. t, J 5.9), 4.44 (2H, br. d, J 5. 9). M/Z (ES+) 352 (M+H+).

As the paragraph descriping shows that 1123-55-3 is playing an increasingly important role.

Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/28445; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15864-32-1, Under a nitrogen atmosphere a solution of 2-amino-6-brombromobenzothiazole (2, 0.00213 mol),acetonitrile (5 mL), and acetic anhydride (0.003 mol) was stirred at 60 C for 40 min with the additionof few drops of conc. H2SO4, After 40 min distilled water (15-20 mL) was added to form a precipitateand stirring was continued for one hour at room temperature. The solution was filtered and washedwith water and the product further analyzed by spectroscopic techniques [25].

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Gull, Yasmeen; Rasool, Nasir; Noreen, Mnaza; Nasim, Faiz-Ul-Hassan; Yaqoob, Asma; Kousar, Shazia; Rashid, Umer; Bukhari, Iftikhar Hussain; Zubair, Muhammad; Islam, Md. Saiful; Molecules; vol. 18; 8; (2013); p. 8845 – 8857;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

[00181] A solution of 6-(trifluoromethyl)benzo[d]thiazole (3) (830 mg, 4.08 mmol) and hydrazine monohydrate (1.52 g, 30.6 mmol) in ethanol (20 mL) was heated to reflux for 1.5 h. The mixture was added to a solution of acetic acid (3 mL) in water (100 mL) and extracted with DCM. The organic extract was dried over Na2S04and concentrated under reduced pressure. The crude material was purified by silica gel chromatography to afford 670 mg (84%) of the title compound as a yellow oil. NMR (400 MHz, CDCI3) delta 7.62 (d, J= 1.2 Hz, 1H), 7.39 (dd, J = 8.4, 2.0 Hz, 1H), 6.75 (d, J= 8.4 Hz, 1H), 4.49 (s, 2H), 2.95 (s, 1H).

131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOGRA PHARMA LIMITED; VITI, Francesca; BELLINVIA, Salvatore; DEMARTIS, Salvatore; (104 pag.)WO2015/197861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 2-araino-l-(4-methoxyphenyl)ethanone hydrochloride (8 mg, 0.04 mmol), benzothiazole-6-carboxylic acid (7 mg, 0.04 mmol), tris(dimethylamino)chloro phosphonium hexafluorophosphate (48 mg, 0.14 mmol), and N,N-diisopropylethylamine (24 muL, 0.14 mmol) in NMP (600 muL) was stirred at room temperature overnight, then the solvents were evaporated in vacuo. The resulting residue was dissolved in acetic anhydride (400 muL) followed by the addition of TFA (100 muL). The reaction mixture was heated at 90 0C for 1 h, cooled to the room temperature, and concentrated in vacuo. The resulting residue was dissolved in DMSO (200 mul) and subjected to HPLC purification (Method T) to provide 6-(5- (4-methoxyphenyl)oxazol-2-yl)benzo[dJthiazole (2 mg). LC/MS (ESI) m/z 309.1 [M+H]. HPLC retention time (Method A) = 3.53 min., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; AMPHORA DISCOVERY CORPORATION; WO2007/149395; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194374-25-8,2-Bromo-5-methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Bromo-5-methylthiazole-4-carboxylic acid (118 mg, 0.5 32 mmol) was suspended in anhydrous DCM (5 mL), and a drop a DMF was added. Then, oxalyl chloride (2 M in DCM) (0.725 mL, 1.45 mmol) was added dropwise, and the reactionmixture was stirred for 1 h at rt (bubbling observed; the mixture became homogeneous). Then, DCM was removed under reduced pressure, and the obtained acid chloride (brown syrup) was used in the subsequent step. In a separate flask, to a suspension of Intermediate 2, HC1 (141 mg, 0.483 mmol) in THF (5 mL), was added DIEA (0.084 mL, 0.483 mmol) and trimethylsilyl cyanide (0.644 mL, 4.83 mmol). The resultant solutionwas stirred at rt for 10 mm, and then was treated with a solution of acid chloride obtained as described above in THF (5 mL). The mixture was stirred at 50 C for 1.5 h. The reaction mixture was concentrated, then trifluoroethanol (10 mL) was added. The residue was purified by flash chromatography (solid loading on CELITE, 0-100% EtOAc/Hex) affording Intermediate 24 (86 mg, 39% yield) as a off-white solid. MS(ESI) m/z: 459.0(M+H) ?H NMR: (400 MHz, CDC13) oe ppm 9.91 (s, 1H), 8.46 (dd, J7.8, 1.0 Hz, 1H),7.86 – 7.80 (m, 1H), 7.80 – 7.74 (m, 1H), 7.70 (d, J8.1 Hz, 1H), 7.37 (br d, J=7.9 Hz,1H), 4.47 (sxt, J=8.2 Hz, 1H), 3.83 (quin, J8.5 Hz, 1H), 2.77 – 2.69 (m, 1H), 2.63 – 2.34(m, 5H), 2.17 (dd,J=10.8, 8.8 Hz, 1H), 2.04- 1.97 (m, 1H), 1.60 (s, 3H)., 1194374-25-8

As the paragraph descriping shows that 1194374-25-8 is playing an increasingly important role.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B) A Schlenck flask was charged with 5-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.33 g, 1.80 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) (0.15 g, 0.26 mmol) and palladium dibenzylideneacetone (Pd2dba3)-chloroform complex (0.08 g, 0.08 mmol). Degassed dioxane (6.00 ml) was added, followed by 3-bromopyridine (0.23 g, 1.50 mmol). The flask was subjected to 5 cycles of evacuation and backfiring with argon. The reaction mixture was then transferred under argon to a microwave vial containing cesium carbonate (0.84 g, 2.60 mmol). The vial was then irradiated in a microwave oven at 150 C. for 10 min. The mixture was diluted with THF and the solids filtered, washing with THF. The filtrate was evaporated and the residue purified by flash chromatography (ethyl acetate/methanol) to yield 2-methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester (0.25 g, 65%) as a light yellow solid, 31785-05-4

As the paragraph descriping shows that 31785-05-4 is playing an increasingly important role.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-07-2,Isothiazol-3(2H)-one,as a common compound, the synthetic route is as follows.

EXAMPLE 8 Isothiazolone composition was prepared by blending 14 wt % of an isothiazolone mixture comprising 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in a weight ratio of 3:1, 1 wt % of N,N’-dimethyl-3,3′-dithiodipropionamide, 1 wt % of N,N’-dimethyl-3-thiodipropionamide, 1 wt % of methyl-3-mercapto propionamide, and 83 wt % of organic solvent, as shown in the following table 8., 1003-07-2

The synthetic route of 1003-07-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sunkyong Industries Co., Ltd.; US5919400; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica