With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188937-16-8,2-(2-Thiazolyl)acetic Acid,as a common compound, the synthetic route is as follows.
To a solution of 5-bromo-4- (4-fluorophenyl) -6-hydrazinylpyrimidin-2-amine (400 mg, 1.3 mmol), 2- (1, 3-thiazol-2-yl) acetic acid (384 mg, 2.7 mmol), TEA (543 mg, 5.4 mmol) in DMSO (10 mL) was added HATU (1.3 g, 3.4 mmol). Stirred at 25C for 4 hours. The resulting mixture was poured into 100 mL water and filtered. The solid was dried in vacuum to afford N- [2-amino-5-bromo-6- (4-fluorophenyl) pyrimidin-4-yl]-2-(1, 3-thiazol-2-yl) acetohydrazide (336 mg, 59%) as a dark-grey solid. LCMS: m/z (ESI), [M+H] + = 423, 4. 1H NMR (300 MHz, DMSO-d 6) delta 4.05 (s, 2H), 6.42 (s, 2H), 7.28 (t, 2H), 7.54-7.70 (m, 3H), 7.75 (d, 1H), 8.75 (s, 1H), 10.22 (s, 1H)., 188937-16-8
The synthetic route of 188937-16-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; ZENG, Qingbei; QI, Changhe; TSUI, Honchung; YANG, Zhenfan; ZHANG, Xiaolin; (206 pag.)WO2020/52631; (2020); A1;,
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