101080-15-3, 5-Isopropylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The thiazole amine (69 mmol) was combined with 2- (S)-tert-butoxycarbonylamino- pentanoic acid (69 mmol) in 170 mL of anhydrous DMF under N2. Triethylamine (76 mmol) was added to the reaction, followed by HOBT (76 mmol) and EDCI (76 mmol). The resultant mixture was stirred at r. t. for 16h. The reaction was then diluted with 200 mL of EtOAc and washed with 200 mL of water and brine. The organics were then dried over Na2SO4, filtered and concentrated under reduced pressure to give the desired product, [1-(5-Isopropyl-thiazol- 2-ylcarbamoyl)-butyl]-carbamic acid ter-butyl ester. The product (10.2 mmol) was purified through flash chromatography and dissolved in 15 mL of anhydrous 4.0 N HCI in dioxane and stirred at rt for 2 h. The reaction was then concentrated under reduced pressure and triturated in Et20 to give the desired amine, 2- Amino-pentanoic acid (5-isopropyl-thiazol-2-yl)-amide, 101080-15-3
The synthetic route of 101080-15-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; PFIZER PRODUCTS INC.; WO2005/95367; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica