With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.
In a suspension of 6-bromobenzo[dlthiazol-2-amine (500 mg, 2.2 mmol), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi( 1 ,3,2-dioxaborolane) (1.1 g, 4.4 mmol), Pd(dppf)C12 (161 mg, 0.2 mmol) and KOAc (754 mg, 7.7 mmol) in 20 mL of dioxane was stirred at 100 C under N2 overnight. The reaction was filtered. And the filtrate was evaporated to give the title compound as a black oil (1.5 g)., 15864-32-1
The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ZHANG, Xiaohu; ACCRO BIOSCIENCE INC.; MA, Haikuo; ZHENG, Jiyue; HE, Sudan; (101 pag.)WO2018/237370; (2018); A1;,
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