With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.943-03-3,6-Methoxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.
943-03-3, STR24 2-Cyano-6-hydroxybenzothiazole. Dry pyridinium hydrochloride (34.0 g, 0.294 mol) and 2-cyano-6-methoxy-benzothiazole (Aldrich Chemical Co., 3.0 g, 0.016 mol) were added into a 500 mL round bottom flask which was preheated in an oil bath at 100° C. The bath temperature was increased to 190° C. and the reaction mixture was refluxed at this temperature for 2 h. After the completion of reaction, it was cooled to room temperature to obtain a yellow solid which was dissolved in methanol. Silica was added to this solution and evaporated to dryness. This material was then chromatographed using 30percent ethyl acetate/hexane to obtain 2.7 g of the product as a white solid (95percent): mp 120° C.; 1 H NMR (CD3 OD) delta 5.68 (bs, 1H), 8.02-8.82 (m, 3H); — C NMR (CD3 OD) delta 106.96, 114.26, 119.59, 126.53, 133.83, 138.93, 147.25, 160.23; MS m/e (rel intensity) 176 (100), 151 (3), 124 (5), 96 (15), 85 (4), 69 (7), 57 (5); Exact mass: calcd 176.0044, found 176.0047. STR25
943-03-3 6-Methoxybenzo[d]thiazole-2-carbonitrile 342109, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Board of Governors of Wayne State University; US5616729; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica