With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1094070-77-5,tert-Butyl (2-bromothiazol-5-yl)carbamate,as a common compound, the synthetic route is as follows.
[00299] 1 , 1 -Dimethylethyl (2-bromo- 1 ,3-thiazol-5 -y l)((2S)-2-(((( 1,1- dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate: To a 250 mL round-bottomed flask was added tert-butyl 2-bromothiazol-5-ylcarbamate (0.75 g, 2.69 mmol), DMF (26.9 mL, 2.69 mmol), and cesium carbonate (1.75 g, 5.37 mmol). The mixture was warmed to 500C and 1,1-dimethylethyl 4-((4-(trifluoromethyl)phenyl)methyl)-l,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (1.13 g, 2.96 mmol, Scheme 1) was added slowly in 10 mL DMF. After 1 hour, the mixture was cooled, diluted with ether (100 mL) and washed with brine (3×50 mL). The organic layer was dried over sodium sulfate, evaporated onto a plug of silica gel and purified by chromatography through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 20 % to 100 % EtOAc in hexane, to provide the product (1.42 g, 91 % yield) as a white amorphous solid. LCMS (API-ES) m/z (%): 582 (100%, M+H).
1094070-77-5, The synthetic route of 1094070-77-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
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