939-69-5, 6-Hydroxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
939-69-5, Method A: Preparation of a 5-Oxymethyl-D-Luciferin Cycloheximide Conjugate [00190] 5-Hydroxymethyl-D-Luciferin. A modification of the procedure of Seto, S., et al., 1963 is used. A mixture of 2-Cyano-6-hydroxybenzthiazole (200 mg), ?-hydroxymethyl D-Cysteine (200 mg), potassium carbonate (160 mg) and 50% aqueous methanol (10 mL) is stirred under a stream of nitrogen gas, at room temperature for 2.5 hours. After neutralization with 1 N aqueous HCl, the precipitate is collected, washed with water and recrystallized from 95% ethanol to give the title compound. [00191] 6′-O-t-butyldimethylsilyl-5-hydroxymethyl-D-Luciferin, t-butyldimethylsilyl ester. Under anhydrous conditions. 5-hydroxymethyl-D-Luciferin (45mg, 0.145 mmole) is dissolved in anhydrous dimethylformamide (7 mL), cooled to 0 C. (ice-bath) and imidazole (300 muL) and t-butyldimethylsilyl chloride solution (50% solution in tetrahydrofuran, 52 muL, 2.1 equiv.) is added. The reaction mixture is allowed to stir at 0 C. for 2 hours and at room temperature overnight. The major product is purified by silicagel column chromatography using dichloromethane:ethylacetate gradient elution. Fractions containing the first major product to elute from the column are combined and evaporated to give the title compound as a white solid.
939-69-5 6-Hydroxybenzo[d]thiazole-2-carbonitrile 9881912, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Marker Gene Technologies, Inc.; US6656917; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica