With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942631-50-7,tert-Butyl thiazol-5-ylcarbamate,as a common compound, the synthetic route is as follows.
942631-50-7, 1.2 thiazo 1-5 -amine hydrochloride To a solution of tert-butyl thiazo 1-5 -ylcarbamate from example 1.1 (20 g, 100 mmol) in methanol (100 mL) was added HCl/dioxane (50 mL). The solution was stirred at room temperature for 2 h. The solution was concentrated to give the title compound as a pale yellow solid (10.9 g, 0.80 mmol, 80%). It was used directly for next step without further purification. LC-MS: m/z 137 (M+H), RT=0.05 min
The synthetic route of 942631-50-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ABBOTT GMBH & CO. KG; ABBVIE INC.; GENESTE, Herve; OCHSE, Michael; DRESCHER, Karla; JAKOB, Clarissa; TORRENT, Maricel; YAO, Shanshan; ZHAO, Xiaoling; WANG, Liang; WO2014/41175; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica