Day: March 25, 2022

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromo-6-methoxybenzothiazole (0.67g) in drydichloromethane (30ml) at ambient temperature under an atmosphere of nitrogen wasadded dropwise a solution of boron tribromide in dichloromethane (5.5ml, 1M). Themixture was stirred for 2 hours at ambient temperature, stored for 2 days then poured intowater. The organic phase was separated, washed with water, dried over magnesiumsulphate then evaporated under reduced pressure to give 2-bromo-6-hydroxy-benzothiazole as a pale pink solid, 0.60g, m.p. 203-204C., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SYNGENTA LIMITED; WO2004/108663; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

824403-26-1, 5-Bromo-2-chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.9 g, 3.62 mmol) in ethanol (12 mL) was added 4M methylamine solution (1 mL) and the mixture was heated for 90 minutes using a Biotage microwave oven at 100C. The reaction mixture was cooled to room temperature. The solvent was removed, the crude product was purified on a silica gel column using an EtOAc and heptane gradient (20/80 => 50/50) to afford the title compound as a solid (0.57 g, 65 %). (0511) 1H-NMR (400 MHz, Chloroform-c/) d = 7.68 (t, J = 2.0 Hz, 1 H), 7.46 (d, J = 8.3 Hz, 1 H), 7.22 (dd, J = 8.4, 1.9 Hz, 1 H), 5.90 (s, 1 H), 3.13 (s, 3H).

824403-26-1, The synthetic route of 824403-26-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The corresponding 2-bromobenzothiazoles 10, 12-15 (0.66mmol, 1equiv) and the corresponding phenylboronic acid pinacol ester (0.79mmol, 1.2equiv) were dissolved in anhydrous DMF in the presence of K2CO3 (6.0equiv). After 1h under argon bubbling, Pd(dppf)Cl2·CH2Cl2 (0.033mmol, 0.05equiv) was introduced and the mixture was stirred at 80C or under microwave irradiation (monitoring by TLC or by GC-MS). Later, the mixture was then filtered on Celite, concentrated and dissolved in 4mL of 1N MeOH/HCl. Then 75mL of Et2O were introduced and a colour powder was isolated by filtration. The precipitate was poured into water and pH adjusted to 6. The expected compounds were isolated by filtration and purity was checked by HPLC., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde; Tetrahedron; vol. 69; 35; (2013); p. 7345 – 7353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14527-44-7, Methyl thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10231] Procedure:10232] Pd(OAc)2 (3.9 mg, 0.017 mmoles), [P(t-13u)3H] HF4 (10.0mg, 0.035 mmoles), 1-adamantanecarboxylic acid (18.4 mg, 0.10 mmoles), K2C03 (96.5 mg, 0.70 mmoles), methyl thiazole-5-carboxylate (50 mg, 0.35 mmoles), and methyl 6-bromonicotinate (113 mg, 0.52 mmoles) were added to a dried flask. The flask was fitted with a reflux condenser capped with a septum, evacuated, and purged with nitrogen (.-5 times). Dry toluene (1.7 mE) was added via syringe, and the reaction was stirred at 110 C. for 48 h. The reaction mixture was cooled and filtered through Celite, and the filtrate was concentrated under reduced pressure. The crude product was then purified by chromatography on silica (3% acetone in 1:1 DCMlhexanes) to afford the title compound (28 mg, 29%) as a white solid. ?H NMR (400 MHz, CDC13) 0 9.22 (s, 1H), 8.51 (s, 1H), 8.43 (dd, J=2.0, 8.0 Hz, 1H), 8.29 (d, J=8.0 Hz, 1H), 4.00 (s, 3H), 3.96 (s, 3H); ?3C NMR (100 MHz, CDC13) 0 172.7, 165.1,161.8, 153.6, 150.9, 149.7, 138.4, 131.7, 127.1, 119.6, 52.6, 52.6; HRMS (ESI) m/z 279.0439 [calc?d for C,2H,,N204S (M+H) 279.0435].10233] For experiments with mammalian cells, this compound was recrystallized from EtOAc to afford a whitecrystalline solid., 14527-44-7

As the paragraph descriping shows that 14527-44-7 is playing an increasingly important role.

Reference：
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

943-03-3, Pyridinium chloride (19.5 g) was added to 6-methoxybenzo [d] thiazole-2-carbonitrile (766 mg, 4.03 mmol) under argon atmosphere at room temperature. The obtained mixture was heated to 200 ° C. under an argon atmosphere to melt the pyridinium chloride and then stirred at 200 ° C. for 1 hour.The reaction mixture was allowed to cool to room temperature, 2 M hydrochloric acid (250 mL) was added, and the mixture was further extracted with ethyl acetate (3 × 100 mL). The combined organic layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (silica gel 85 g; hexane-ethyl acetate (1: 1)) to give 6-hydroxybenzo [d] thiazole-2-carbonitrile

As the paragraph descriping shows that 943-03-3 is playing an increasingly important role.

Reference：
Patent; KEIO UNIVERSITY; SAITOH, TSUYOSHI; NISHIYAMA, SHIGERU; IOKA, SHUJI; MAKI, SHOJIRO; NIWA, HARUKI; (19 pag.)JP6095208; (2017); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

59418-09-6,59418-09-6, Methyl 4-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under nitrogen atmosphere, a sealable reaction tube equipped with a magnetic stirrer bar was charged with azole (0.50 mmol), sodium arylsulfinate (1.0 mmol), Pd(OAc)2 (0.025 mmol), Cu(OAc)2 (1.0 mmol), CF3COOH (0.50 mmol), and dimethylglycol (2.0 mL). The rubber septum was then replaced by a Teflon-coated screw cap, and the reaction vessel placed in an oil bath at 120 C for 24 h. After the reaction was completed, it was cooled to room temperature and the mixture was treated with K2CO3 solution (1.0 mol/L, 3.0 mL), then extracted with ethyl acetate. The resulting solution was dried by Na2SO4 then concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (eluant: petroleum ether/ethyl acetate=12:1, v/v) to give the desired product.

The synthetic route of 59418-09-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Wang, Min; Li, Dengke; Zhou, Wei; Wang, Lei; Tetrahedron; vol. 68; 7; (2012); p. 1926 – 1930;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 5-amino-2-methylthiazole-4-carboxylate (1.7 g, 9.0 mmol), 1-bromo-2- methoxyethane (1.2 g, 9.0 mmol) and C52CO3 (4.4 g, 13.5 mmol) in DMF (10 mL) was heatedto 50 C for 7 hours and then cooled to r.t. The crude product was purified by reverse phaseC18 column chromatography (MeCN/H20) to give ethyl 5-((2-methoxyethyl)amino)-2-methylthiazole-4-carboxylate as an orange oil (850 mg, 3.48 mmol, 39%). ESI-MS m/z: 245.2[M+Hj ., 31785-05-4

31785-05-4 Ethyl 5-amino-2-methylthiazole-4-carboxylate 13329095, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; OR, Yat, Sun; (434 pag.)WO2017/15449; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64987-16-2,Methyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.

64987-16-2, To a mixture of tert-butyl nitrite (10 mL, 80 mmol) and CuCN (7.28 g, 80 mmol) in anhydrous acetonitrile (30 mL) was added a solution of ethyl 2-(2-aminothiazol-4-yl)acetate (7.5 g, 40 mmol) in anhydrous acetonitrile (20 mL) dropwise over a period of 1 hour at 50 C., then the mixture was stirred at the temperature for 2.5 hours. The mixture was concentrated in vacuo and the residue was purified by a silica gel column chromatography (PETROLEUM ETHER/EtOAc (V/V)=25/1) to give the title compound as yellowish liquid (2 g, 25%). The compound was characterized by the following spectroscopic data: 1H NMR (400 MHz, DMSO-d6): delta 4.01 (q, 2H), 3.72 (s, 2H), 1.16 (t, 3H).

64987-16-2 Methyl 2-(2-aminothiazol-4-yl)acetate 738059, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; LIU, Xinchang; GOLDMANN, Siegfried; US2015/152096; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

31785-05-4, To a solution of 5-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (15.0 g, 0.081 mol) in DCM (550 mL) was added chlorosulfonyl isocyanate (8.92 mL, 0.102 mol) dropwise at -78 0C. The thick suspension was allowed to warm to RT and stirred for 45 minutes. The resulting precipitate was collected by filtration and dried in vacuo. The resultant white solid was suspended in an aqueous solution of HCl (6 M, 400 mL) and heated at 90 C for 1 h. The resulting solution was cooled to 0 C and pH adjusted to 5 with an aqueous solution of NaOH (6 M). The resultant precipitate was collected by filtration and dried in vacuo at 60 C for 36 h to give the title compound (16.4 g, 89 %). [M + H]+ 230.0

31785-05-4 Ethyl 5-amino-2-methylthiazole-4-carboxylate 13329095, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; F.HOFFMANN-LA ROCHE AG; WO2008/152390; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.943-03-3,6-Methoxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.

943-03-3, STR24 2-Cyano-6-hydroxybenzothiazole. Dry pyridinium hydrochloride (34.0 g, 0.294 mol) and 2-cyano-6-methoxy-benzothiazole (Aldrich Chemical Co., 3.0 g, 0.016 mol) were added into a 500 mL round bottom flask which was preheated in an oil bath at 100° C. The bath temperature was increased to 190° C. and the reaction mixture was refluxed at this temperature for 2 h. After the completion of reaction, it was cooled to room temperature to obtain a yellow solid which was dissolved in methanol. Silica was added to this solution and evaporated to dryness. This material was then chromatographed using 30percent ethyl acetate/hexane to obtain 2.7 g of the product as a white solid (95percent): mp 120° C.; 1 H NMR (CD3 OD) delta 5.68 (bs, 1H), 8.02-8.82 (m, 3H); — C NMR (CD3 OD) delta 106.96, 114.26, 119.59, 126.53, 133.83, 138.93, 147.25, 160.23; MS m/e (rel intensity) 176 (100), 151 (3), 124 (5), 96 (15), 85 (4), 69 (7), 57 (5); Exact mass: calcd 176.0044, found 176.0047. STR25

943-03-3 6-Methoxybenzo[d]thiazole-2-carbonitrile 342109, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Board of Governors of Wayne State University; US5616729; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica