Can You Really Do Chemisty Experiments About 92-71-7

Here is just a brief introduction to this compound(92-71-7)HPLC of Formula: 92-71-7, more information about the compound(2,5-Diphenyloxazole) is in the article, you can click the link below.

HPLC of Formula: 92-71-7. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,5-Diphenyloxazole, is researched, Molecular C15H11NO, CAS is 92-71-7, about Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles. Author is Narita, Koichi; Suganuma, Keisuke; Murata, Toshihiro; Kondo, Ryutaro; Satoh, Hiroka; Watanabe, Kazuhiro; Sasaki, Kenroh; Inoue, Noboru; Yoshimura, Yuichi.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. The trypanocidal activities of the synthesized compounds were evaluated against Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. congolense, and T. evansi. Natural product 1 exhibited trypanocidal activity against all the species/subspecies of trypanosomes, exhibiting half-maximal inhibitory concentrations (IC50) of 1.1-13.5 μM. Modification of the oxazole core improved the trypanocidal activity. The 1,3,4-oxadiazole (7) and 2,4-diphenyloxazole (9) analogs exhibited potency superior to that of 1. However, these compounds exhibited cytotoxicity in Madin-Darby bovine kidney cells. The O-methylated analog of 1 (12) was non-cytotoxic and exhibited selective trypanocidal activity against T. congolense (IC50 = 0.78 μM). Structure-activity relationship studies of the 2,5-diphenyloxazole analogs revealed aspects of the mol. structure critical for maintaining selective trypanocidal activity against T. congolense.

Here is just a brief introduction to this compound(92-71-7)HPLC of Formula: 92-71-7, more information about the compound(2,5-Diphenyloxazole) is in the article, you can click the link below.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica