The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,5-Diphenyloxazole( cas:92-71-7 ) is researched.Recommanded Product: 92-71-7.Liu, Chengwei; Ji, Chong-Lei; Zhou, Tongliang; Hong, Xin; Szostak, Michal published the article 《Bimetallic Cooperative Catalysis for Decarbonylative Heteroarylation of Carboxylic Acids via C-O/C-H Coupling》 about this compound( cas:92-71-7 ) in Angewandte Chemie, International Edition. Keywords: chemoselective synthesis heterobiaryl decarbonylative heteroarylation carboxylic acid heteroarene; bimetallic cooperative catalysis chemoselective synthesis heterobiaryl; C−O/C−H bond activation; bimetallic catalysts; carboxylic acids; decarbonylation; heteroarylation. Let’s learn more about this compound (cas:92-71-7).
Cooperative bimetallic catalysis is a fundamental approach in modern synthetic chem. We report bimetallic cooperative catalysis for the direct decarbonylative heteroarylation of ubiquitous carboxylic acids via acyl C-O/C-H coupling [e.g., benzoxazole + benzoic acid → 2-phenylbenzoxazole (92%)]. This novel catalytic system exploits the cooperative action of a copper catalyst and a palladium catalyst in decarbonylation, which enables highly chemoselective synthesis of important heterobiaryl motifs through the coupling of carboxylic acids with heteroarenes in the absence of prefunctionalization or directing groups. This cooperative decarbonylative method uses common carboxylic acids and shows a remarkably broad substrate scope (>70 examples), including late-stage modification of pharmaceuticals and streamlined synthesis of bioactive agents. Extensive mechanistic and computational studies were conducted to gain insight into the mechanism of the reaction. The key step involves intersection of the two catalytic cycles via transmetalation of the copper-aryl species with the palladium(II) intermediate generated by oxidative addition/decarbonylation.
Here is just a brief introduction to this compound(92-71-7)Recommanded Product: 92-71-7, more information about the compound(2,5-Diphenyloxazole) is in the article, you can click the link below.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica