Analyzing the synthesis route of 15448-99-4

15448-99-4 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide 27290, athiazole compound, is more and more widely used in various fields.

15448-99-4, 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,15448-99-4

EXAMPLE 7 Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (I; Y=OCH3) In a manner similar to Example 6, 864 mg. (0.036 mole) of 99% sodium hydride was added over a two hour period to a solution of 2.9 g. (0.015 mole) of N-methylsaccharin and 9.8 g. (0.09 mole) of methylchloroacetate in 10 ml. of dimethylsulfoxide at 40 C. Stirring was continued at 40-45 C. for an additional two hours, and the reaction mixture was poured into 150 ml. of 5% hydrochloric acid solution. The precipitate was filtered and dried to give 3.07 (76%) of the desired product.

15448-99-4 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide 27290, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; Pfizer Inc.; US4376204; (1983); A;; ; Patent; Pfizer Inc.; US4483982; (1984); A;,
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New learning discoveries about 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Bromobenzo[d]thiazol-2-amine (2.3 g, 10.0 mmol) was suspended in dichloromethane (30 ml), and then 4-dimethylaminopyridine (1.3 g, 11.5 mmol) was added. The mixture was cooled in an ice-water bath under nitrogen, and acetic anhydride (1.0 ml, 11.5 mmol) was added. The resulting mixture was allowed to slowly warm to room temperature while being stirred overnight under nitrogen. Then hydrochloric acid (10%, 10 ml) was added and 5b (2.3 g, 85%) was obtained by filtration as white solid. Mp: 217.0-218.0 C; 1H NMR (DMSO-d6): delta 12.46 (s, 1H, NH), 8.24 (s, 1H, Ar-H), 7.67 (d, J = 7.2 Hz, 1H, Ar-H), 7.57 (d, J = 6.8 Hz, 1H, Ar-H), 2.21 (s, 3H, CH3). ESI-HRMS m/z: calcd for C9H7BrN2NaOS [M+Na]+: 292.9360; found 292.9360., 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Huan; Wang, Xiao-Meng; Wang, Juan; Shao, Teng; Li, Yi-Ping; Mei, Qi-Bing; Lu, She-Min; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 22; 14; (2014); p. 3739 – 3748;,
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Analyzing the synthesis route of 40283-41-8

The synthetic route of 40283-41-8 has been constantly updated, and we look forward to future research findings.

40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the solution of 4-sulfamoylbenzoic acid (200 mg, 0.53 mmol) inMeOH (8 mL) added SOCl2 (1348 muL, 1.84 mmol) at 0 C. The mixturewas stirred at 40 C for 2 h, and then concentrated. Ester (214 mg,1.00 mmol) and (Boc)2O (238 mg, 1.09 mmol) were dissolved in DCM(8 mL). Et3N (138 muL, 1 mmol) and DMAP (12.2 mg, 0.1 mmol) wereadded and the mixture was stirred at rt. for 1.5 h. The solution wasconcentrated and purified to afford methyl 4-(N-(tert-butoxycarbonyl)sulfamoyl)benzoate. DIBAL-H (2 mL, 2 mmol) was added slowly tomethyl benzoate (300 mg, 1.00 mmol) in DCM (8 mL) at -78 C and themixture was stirred at -78 C for 2 h. The reaction was quenched by MeOH (2 mL), and then warmed to 0 C and added 10% citric acidunder stirring. The mixture was extracted with DCM, and the organicswere washed, dried, concentrated and purified to afford 4-formylbenzenesulfonamide.Using 4-formylbenzenesulfonamide, thecompound 44 was obtained from 5 by the general procedure as above.To the solution of 44 (95 mg, 0.20 mmol) in DCM (4 mL) added TFA(300 muL, 0.04 mmol). The mixture was stirred at rt. for 1 h. The solutionwas adjusted to pH 7-8 by NaHCO3. The mixture was extracted withEA, and the organics were washed, dried, concentrated and purified toafford 17, 54% yield for five steps, 94.0% HPLC purity., 40283-41-8

The synthetic route of 40283-41-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Lingling; Chen, Yang; He, Junlin; Njoya, Emmanuel Mfotie; Chen, Jianjun; Liu, Siyan; Xie, Congqiang; Huang, Wenze; Wang, Fei; Wang, Zhouyu; Li, Yuzhi; Qian, Shan; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1087 – 1098;,
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Downstream synthetic route of 3622-38-6

3622-38-6, The synthetic route of 3622-38-6 has been constantly updated, and we look forward to future research findings.

3622-38-6, 2-Chloro-5-nitrobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 62 In 7.4 ml of tetrahydrofuran was dissolved 160 mg of 2-chloro-5-nitro-1,3-benzothiazole, and thereto was added 1.86 ml of a 1M dimethylamine tetrahydrofuran solution, followed by 16.5 hours of stirring. Water was added to the reaction solution and the organic layer was extracted with ethyl acetate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed by evaporation. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to obtain 173 mg of N,N-dimethyl-5-nitro-1,3-benzothiazol-2-amine as a yellow solid.

3622-38-6, The synthetic route of 3622-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP1632477; (2006); A1;,
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Some tips on 943-03-3

The synthetic route of 943-03-3 has been constantly updated, and we look forward to future research findings.

943-03-3,943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The methoxycarbonitrile derivative (1 eq) was mixed with pyridinium chloride (5 eq) under argon and heated to 210°C for 30 minutes. The resulting mixture was partitioned between distilled water and dicloromethane, and the organic layers were concentrated under vacuum. The crude product was dissolved in 5 percent Na2CO3 (50 ml) and filtered before addition of HCl until pH ?4.0. The aqueous layer was extracted with dichloromethane (50 mL) and the organic layers removed under vacuum yielding pure product (>98percent).

The synthetic route of 943-03-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rothweiler, Ulli; Eriksson, Jonas; Stensen, Wenche; Leeson, Frederick; Engh, Richard A.; Svendsen, John S.; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 140 – 148;,
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Some tips on 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-bromo-6- methoxybenzo[d]thiazole (0.90 g; 3.7 mmol) was dissolved in CH2CI2 (50 mL). BBr3 (1M in CH2C12, 16 mL, 16 mmol) was added slowly. White precipitate formed immediately. After overnight, HPLC showed complete conversion. Excess CH2CI2 (200 mL) and brine (100 mL) were added. White precipitate formed immediately. The mixture was stirred at RT for 2 hours, until most solid dissolved. The organic layer was separated, and aqueous layer extracted with 2 x 100 mL CH2CI2. The combined organic solution was dried over MgS04. The solvent was removed to afford 0.71 g of product. Yield 83%., 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; CAI, Lisheng; PIKE, Victor W.; WO2013/40183; (2013); A1;,
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Simple exploration of 42270-37-1

42270-37-1 2-(Piperazin-1-yl)thiazole 911806, athiazole compound, is more and more widely used in various fields.

42270-37-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 50B 1-phenyl-3-[4-(1,3-thiazol-2-yl)piperazin-1-yl]propan-1-one 3-Chloropropiophenone (8 g, 47.44 mmol), the product from Example 50A (8.83 g, 52.18 mmol), and K2CO3 (6.56 g, 47.44 mmol) were combined in DMF and heated at 35 C. for 16 hours. The mixture was allowed to cool to room temperature, diluted with water, and extracted with ethyl acetate. The ethyl acetate extract was dried over anhydrous Na2CO3, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 1:1 ethyl acetate:hexanes) to provide the title compound. 1H NMR (300 MHz, CDCl3) delta 2.65 (br.s, 4H), 2.95 (br.s, 2H), 3.22 (br.s. 2H), 3.22 (br.s, 2H), 3.45 (br.s, 4H), 6.45 (d, J=3 Hz, 1H), 7.2 (d, J=3 Hz, 1H), 7.45 (m, 2H), 7.6 (m,1H), 7.9 (m, 2H); MS (DCI/NH3) m/z 302 (M+H)+. Anal. calcd for C16H19N3OS: C, 63.76; H, 6.35; N, 13.94. Found: C, 61.50; H, 6.43; N, 13.21.

42270-37-1 2-(Piperazin-1-yl)thiazole 911806, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; Kolasa, Teodzyj; Patel, Meena; Mortell, Kathleen H.; Matulenko, Mark A.; Hakeem, Ahmed A.; Bhatia, Pramila A.; Wang, Xueqing; Daanen, Jerome F.; Latshaw, Steven P.; Stewart, Andrew O.; US2005/176727; (2005); A1;,
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Brief introduction of 30132-15-1

30132-15-1 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid 757163, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30132-15-1,2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid,as a common compound, the synthetic route is as follows.

B. To prepare the intermediate methyl (2-amino-benzothiazol-6-yl)acetate, 2 mL concentrated H2SO4 was added dropwise to a solution of (2-amino-1,3-benzothiazol-6-yl)acetic acid (7.89 g, 37.9 mmol) in 200 mL methanol and the reaction mixture was heated at 50 C. for 90 minutes. After evaporation of most of the methanol, dichloromethane (150 mL) was added and the mixture was neutralized with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane. The organic extracts were combined, dried over MgSO4, and concentrated to give the product as a yellow solid (6.51 g, 77%). 1H NMR (DMSO-d6) delta 7.54 (s, 1H), 7.44 (br, 2H), 7.27 (d, 1H), 7.09 (d, 1H), 3.66 (s, 2H), 3.61 (s, 3H); LC-MS: ESI 223 (M+H)+., 30132-15-1

30132-15-1 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid 757163, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.; US2007/232604; (2007); A1;,
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Simple exploration of 14779-17-0

14779-17-0, As the paragraph descriping shows that 14779-17-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14779-17-0,2-Amino-5-methylbenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a 10 mL round bottom flask was added 0.5 mmolof the amine and 0.1 mL of acetic anhydride. The reactionis instantaneous and exothermic, and after 10 s the solidproduct formed was filtered and washed with cold water.When no solid was immediately formed, 4 mL of coldwater was added, and the mixture allowed standing ina refrigerator for 24 h, leading to precipitation. To allsynthesized acetamides, measured physical data were inagreement to the reported values.17-19,27,31,32

14779-17-0, As the paragraph descriping shows that 14779-17-0 is playing an increasingly important role.

Reference:
Article; Cunha, Silvio; De Santana, Lourenco L. B.; Journal of the Brazilian Chemical Society; vol. 28; 6; (2017); p. 1137 – 1144;,
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Brief introduction of 939-69-5

As the paragraph descriping shows that 939-69-5 is playing an increasingly important role.

939-69-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.939-69-5,6-Hydroxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.

Example 4 Synthesis of Compounds 4 and 13 2-Cyano-6-t-butyldiphenylsiloxy-benzothiazole. A solution of 2-cyano-6-hydroxybenzothiazole (5.0 g, 28 mmol) in 100 ml of anhydrous DMF under inert atmosphere was treated with 2.9 g of imidazole (4.2 mmol) followed by t-butyldiphenylchlorosilane (9.34 g, 34 mmol). The reaction was stirred at room temperature for 3 h and then diluted with 200 ml of ethyl acetate and washed with water (4*400 ml). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography, eluding with 5-10percent ethyl acetate/hexanes to afford 13.0 g of the desired product containing ~10percent silyl impurity in quantitative yield. The product was taken on without further purification. 1 H NMR (CDCl3): delta1.12 (s, 9H); 7.13-7.46 (m, 8H); 7.70-7.72 (m, 4H); 7.92-7.95 (d, 1H).

As the paragraph descriping shows that 939-69-5 is playing an increasingly important role.

Reference:
Patent; Lumigen, Inc.; US5965736; (1999); A;,
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