So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Davies, Douglas R.; Mamat, Bjorn; Magnusson, Olafur T.; Christensen, Jeff; Haraldsson, Magnus H.; Mishra, Rama; Pease, Brian; Hansen, Erik; Singh, Jasbir; Zembower, David; Kim, Hidong; Kiselyov, Alex S.; Burgin, Alex B.; Gurney, Mark E.; Stewart, Lance J. researched the compound: Boc-D-Prolinol( cas:83435-58-9 ).Formula: C10H19NO3.They published the article 《Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography》 about this compound( cas:83435-58-9 ) in Journal of Medicinal Chemistry. Keywords: leukotriene hydrolase inhibitor drug discovery metabolomics crystallog structure activity; drug screening leukotriene hydrolase inhibitor preparation structure activity crystallog. We’ll tell you more about this compound (cas:83435-58-9).
We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small mols. of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding. We screened the FOL library against leukotriene A4 hydrolase (LTA4H) by X-ray crystallog. A diverse set of fragments including derivatives of resveratrol, nicotinamide, and indole were identified as efficient ligands for LTA4H. These fragments were elaborated in a small number of synthetic cycles into potent inhibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis. Anal. of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chem. features and binding modes of several reported LTA4H inhibitors.
If you want to learn more about this compound(Boc-D-Prolinol)Formula: C10H19NO3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(83435-58-9).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica