The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis, the main research direction is phthalazinone derivative preparation intranasal antihistamine H1 H3 allergic rhinitis.Quality Control of Boc-D-Prolinol.
A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogs (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, resp., vs 9.7 for the clin. gold-standard azelastine), and H3 potency (pKi 9.6 and 9.5, resp., vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clin. dose, should limit the potential of engaging CNS-related side-effects associated with H1 or H3 antagonism.
There is still a lot of research devoted to this compound(SMILES：O=C(N1[C@@H](CO)CCC1)OC(C)(C)C)Quality Control of Boc-D-Prolinol, and with the development of science, more effects of this compound(83435-58-9) can be discovered.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica