Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 83435-58-9, is researched, SMILESS is O=C(N1[C@@H](CO)CCC1)OC(C)(C)C, Molecular C10H19NO3Journal, Bioorganic & Medicinal Chemistry Letters called 2-(Aryloxymethyl) azacyclic analogs as novel nicotinic acetylcholine receptor (nAChR) ligands, Author is Elliott, Richard L.; Kopecka, Hana; Gunn, David E.; Lin, Nan-Horng; Garvey, David S.; Ryther, Keith B.; Holladay, Mark W.; Anderson, David J.; Campbell, Jeffrey E., the main research direction is azetidine aryloxymethyl preparation nicotinic acetylcholine receptor; pyrrolidine aryloxymethyl preparation nicotinic acetylcholine receptor; nicotinic acetylcholine receptor ligand aryloxymethyl azacycle.Electric Literature of C10H19NO3.
A series of 2-(aryloxymethyl)azetidine and -pyrrolidine nAChR ligands in which the 3-pyridyl moiety of a previously described series was replaced by a substituted Ph group was explored. Aromatic substitution afforded analogs with Ki values ranging from 3 to >10,000 nM. Generally, substitution at the ortho- and para-position was unfavorable, whereas electron-withdrawing groups at the meta-position improved the Ki values.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica