So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng researched the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0 ).SDS of cas: 1416134-49-0.They published the article 《A New Synthetic Route to Avibactam: Lipase Catalytic Resolution and the Simultaneous Debenzylation/Sulfation》 about this compound( cas:1416134-49-0 ) in Organic Process Research & Development. Keywords: Avibactam sodium improved scalable synthesis Lipase catalytic resolution; Lipase catalytic resolution simultaneous debenzylation sulfation scalable Avibactam preparation. We’ll tell you more about this compound (cas:1416134-49-0).
An efficient synthesis of avibactam starting from com. available ethyl-5-hydroxypicolinate was completed in ten steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which are valuable precursors of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. An optimized one-pot debenzylation / sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica