So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dolewski, Ryan D.; Fricke, Patrick J.; McNally, Andrew researched the compound: Boc-D-Prolinol( cas:83435-58-9 ).Product Details of 83435-58-9.They published the article 《Site-Selective Switching Strategies to Functionalize Polyazines》 about this compound( cas:83435-58-9 ) in Journal of the American Chemical Society. Keywords: functionalize polyazine preparation; switchable control carbon phosphorus bond formation. We’ll tell you more about this compound (cas:83435-58-9).
Many drug fragments and therapeutic compounds contain multiple pyridines and diazines. Developing site-selective reactions where specific C-H bonds can be transformed in polyazine structures would enable rapid access to valuable derivatives Authors present a study that addresses this challenge by selectively installing a phosphonium ion as a versatile functional handle. Inherent factors that control site-selectivity are described along with mechanistically driven approaches for site-selective switching, where the C-+PPh3 group can be predictably installed at other positions in the polyazine system. Simple protocols, readily available reagents, and application to complex drug-like mols. make this approach appealing to medicinal chemists.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica