So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Holmes, Jane L.; Almeida, Lynsie; Barlaam, Bernard; Croft, Rosemary A.; Dishington, Allan P.; Gingipalli, Laksmaiah; Hassall, Lorraine A.; Hawkins, Janet L.; Ioannidis, Stephanos; Johannes, Jeffrey W.; McGuire, Thomas M.; Moore, Jane E.; Patel, Anil; Pike, Kurt G.; Pontz, Timothy; Wu, Xiaoyun; Wang, Tao; Zhang, Hai-Jun; Zheng, Xiaolan researched the compound: 1-Aminopyrrole-2-carboxamide( cas:159326-69-9 ).Electric Literature of C5H7N3O.They published the article 《Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles》 about this compound( cas:159326-69-9 ) in Synthesis. Keywords: fused heterocycle preparation. We’ll tell you more about this compound (cas:159326-69-9).
Examples of hydroxymethylated analogs of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones were sparse or non-existent in the scientific literature. Synthesis of such compounds by using standard procedures from readily available raw materials was demonstrated.
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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica