Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 83435-58-9, is researched, Molecular C10H19NO3, about Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors, the main research direction is pyridinyl ether preparation nicotinic acetylcholine receptor; nicotininc cholinergic receptor azedidinylmethoxy pyrrolidinylmethoxy pyridine.Electric Literature of C10H19NO3.
Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotinic acetylcholine receptors (nAChRs) have suggested an opportunity to develop subtype-selective nAChR ligands for the treatment of specific CNS disorders with reduced side effect liabilities. The synthesis of a novel series of 3-pyridyl ether compounds was reported which possess subnanomolar affinity for brain nAChRs and differentially activate subtypes of neuronal nAChRs. The synthesis and structure-activity relationships for the leading members of the series are described, including A-85380, which possesses ca. 50 pM affinity for rat brain [3H]-(-)-cytisine binding sites and 163% efficacy compared to nicotine to stimulate ion flux at human α4β2 nAChR subtype, and A-84543, which exhibits 84-fold selectivity to stimulate ion flux at human α4β2 nAChR subtype compared to human ganglionic type nAChRs. Computational studies indicate that a reasonable superposition of a low energy conformer of A-85380 with (S)-nicotine and (-)-epibatidine can be achieved. An example compound are (S)-3-[(1-methyl-2-pyrrolidinyl)methoxy]pyridine and (S)-3-(1-methyl-2-azetidinylmethoxy)pyridine.
In addition to the literature in the link below, there is a lot of literature about this compound(Boc-D-Prolinol)Electric Literature of C10H19NO3, illustrating the importance and wide applicability of this compound(83435-58-9).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica