Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 83435-58-9, is researched, Molecular C10H19NO3, about Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts, the main research direction is alkylheterocycle regioselective preparation; heterocyclic phosphonium salt preparation organozinc alkylation cobalt catalyst; alkyl Negishi; alkylation; cobalt-catalysis; cross-coupling; late-stage; phosphonium salts; pyridines.Application of 83435-58-9.
Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.
In addition to the literature in the link below, there is a lot of literature about this compound(Boc-D-Prolinol)Application of 83435-58-9, illustrating the importance and wide applicability of this compound(83435-58-9).
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica