In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Identification and Structure-Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors, published in 1998-02-12, which mentions a compound: 83435-58-9, mainly applied to neuronal nicotinic acetylcholine receptor agonist preparation; azetidinylmethoxychloropyridine preparation analgesic; structure activity relationship azetidinylmethoxychloropyridine analgesic; epibatidine analog preparation analgesic, Name: Boc-D-Prolinol.
New members of a previously reported series of 3-pyridyl ether compounds are disclosed as novel, potent analgesic agents acting through neuronal nicotinic acetylcholine receptors. Both (R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594, I) and its S-enantiomer (II) show potent analgesic activity in the mouse hot-plate assay following either i.p. (i.p.) or oral (po) administration, as well as activity in the mouse abdominal constriction (writhing) assay, a model of persistent pain. Compared to the S-enantiomer and to the prototypical potent nicotinic analgesic agent (±)-epibatidine (III), I shows diminished activity in models of peripheral side effects. Structure-activity studies of analogs related to I and II suggest that the N-unsubstituted azetidine moiety and the 2-chloro substituent on the pyridine ring are important contributors to potent analgesic activity.
This literature about this compound(83435-58-9)Name: Boc-D-Prolinolhas given us a lot of inspiration, and I hope that the research on this compound(Boc-D-Prolinol) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica