Wang, Tao; Du, Liang-Dong; Wan, Ding-jian; Li, Xiang; Chen, Xin-Zhi; Wu, Guo-Feng published an article about the compound: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide( cas:1416134-49-0,SMILESS:O=C([C@H]1NC[C@H](NOCC2=CC=CC=C2)CC1)N ).Recommanded Product: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1416134-49-0) through the article.
An efficient synthesis of avibactam starting from com. available ethyl-5-hydroxypicolinate was completed in ten steps and 23.9% overall yield. The synthesis features a novel lipase-catalyzed resolution, in the preparation of (2S,5S)-5-hydroxypiperidine-2-carboxylate acid, which are valuable precursors of the key intermediate Et (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylate. An optimized one-pot debenzylation / sulfation reaction, followed by cation exchange, gave the avibactam sodium salt on a 400.0 g scale.
As far as I know, this compound(1416134-49-0)Recommanded Product: (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxamide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica